Hanjie Jiang
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Explore the profile of Hanjie Jiang including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
417
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Recent Articles
1.
Xie X, Zhang O, Yeo M, Lee C, Tao R, Harry S, et al.
Nature
. 2025 Feb;
639(8053):241-249.
PMID: 39939763
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function. As a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma, the most...
2.
Yeo M, Zhang O, Xie X, Nam E, Payne N, Gosavi P, et al.
Nature
. 2025 Feb;
639(8053):232-240.
PMID: 39939761
UM171 is a potent agonist of ex vivo human haematopoietic stem cell self-renewal. By co-opting KBTBD4, a substrate receptor of the CUL3-RING E3 ubiquitin ligase (CRL3) complex, UM171 promotes the...
3.
Choi J, Im H, Heo J, Kim D, Jiang H, Stark A, et al.
Nat Commun
. 2024 Dec;
15(1):10282.
PMID: 39622817
Efficient light generation from triplet states of organic molecules has been a hot yet demanding topic in academia and the display industry. Herein, we propose a strategy for developing triplet...
4.
Cao R, Gozlan O, Airich A, Tveriakhina L, Zhou H, Jiang H, et al.
Structure
. 2024 Aug;
32(10):1667-1676.e5.
PMID: 39121852
Mind bomb 1 (MIB1) is a RING E3 ligase that ubiquitinates Notch ligands, a necessary step for induction of Notch signaling. The structural basis for binding of the JAG1 ligand...
5.
Jiang H, Miller B, Viennet T, Kim H, Lee K, Arthanari H, et al.
Nat Chem
. 2024 Jul;
16(11):1894-1905.
PMID: 39030419
Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of protein stability and cell signalling in normal and disease states. There are gaps in our...
6.
Lee K, Barone M, Waterbury A, Jiang H, Nam E, DuBois-Coyne S, et al.
Nat Chem Biol
. 2024 Jul;
21(2):227-237.
PMID: 38965385
Biochemical crosstalk between two or more histone modifications is often observed in epigenetic enzyme regulation, but its functional significance in cells has been difficult to discern. Previous enzymatic studies revealed...
7.
Yeo M, Zhang O, Xie X, Nam E, Payne N, Gosavi P, et al.
bioRxiv
. 2024 May;
PMID: 38798619
UM171 is a potent small molecule agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal, a process that is tightly controlled by epigenetic regulation. By co-opting KBTBD4, a substrate...
8.
Xie X, Zhang O, Yeo M, Lee C, Harry S, Paul L, et al.
bioRxiv
. 2024 May;
PMID: 38798357
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function . As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma (MB)...
9.
Cao R, Gozlan O, Tveriakhina L, Zhou H, Jiang H, Cole P, et al.
bioRxiv
. 2024 Mar;
PMID: 38464278
Mind bomb 1 (MIB1) is a RING E3 ligase that ubiquitinates Notch ligands, a necessary step for induction of Notch signaling. The structural basis for binding of the JAG1 ligand...
10.
Wright K, Nathan S, Jiang H, Xia W, Kim H, Chakouri N, et al.
J Biol Chem
. 2024 Feb;
300(3):105715.
PMID: 38309503
NEDD4L is a HECT-type E3 ligase that catalyzes the addition of ubiquitin to intracellular substrates such as the cardiac voltage-gated sodium channel, Na1.5. The intramolecular interactions of NEDD4L regulate its...