Hamada S Abulkhair
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Explore the profile of Hamada S Abulkhair including associated specialties, affiliations and a list of published articles.
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45
Citations
480
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Recent Articles
1.
Abulkhair H
Arch Pharm (Weinheim)
. 2024 Dec;
358(1):e2400802.
PMID: 39655374
Developing new molecular entities is one of the most emerging research areas in the field of Medicinal Chemistry. Over the past few years, rigorous research has been conducted on sulfaguanidine-linked...
2.
Husseiny E, Abulkhair H, El-Sebaey S, Sayed M, Anwer K
Future Med Chem
. 2024 Nov;
16(23):2487-2505.
PMID: 39530543
The structural optimization of our recently reported CDK9 inhibitor to furnish novel aminopyrazolones and methylpyrazolones with improved pharmacokinetics. The synthesis of the targeted compounds was accomplished via conventional, grinding and...
3.
Shaaban S, Hammouda M, Althikrallah H, Al Nawah J, Ba-Ghazal H, Sharaky M, et al.
Curr Med Chem
. 2024 Aug;
PMID: 39136522
Background: Organoselenium (OSe) agents and Schiff bases have demonstrated immense potential in the pharmaceutical field due to their broad spectrum of medicinal activities. Methods: We herein report the antitumor activities...
4.
Aouadi A, Hamada Saud D, Rebiai A, Achouri A, Benabdesselam S, Abd El-Mordy F, et al.
Sci Rep
. 2024 Jun;
14(1):14753.
PMID: 38926522
The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability of the procedure for synthesizing such nanoparticles...
5.
Abdulrahman F, Abulkhair H, Zidan R, Alwakeel A, Al-Karmalawy A, Husseiny E
Future Med Chem
. 2024 Jan;
16(2):105-123.
PMID: 38226455
A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α inhibition was identified. A bioisosterism-aided approach was applied to design new benzochromenes and assess their cytotoxicity against three cancer...
6.
Abdulrahman F, Abulkhair H, El Saeed H, El-Dydamony N, Husseiny E
Bioorg Chem
. 2024 Jan;
144:107105.
PMID: 38219482
As regards to the structural analysis and optimization of diverse potential EGFR inhibitors, two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl imidazolylthiomethylacrylates were designed and constructed as potential EGFR suppressors. The cytotoxic...
7.
Husseiny E, Abulkhair H, Saleh A, Altwaijry N, Zidan R, Abdulrahman F
Bioorg Chem
. 2023 Aug;
140:106789.
PMID: 37611530
Adopting the molecular overlay approach, three novel sets of thiazepinopurines with expected cytotoxicity and CDK2 inhibition potential were designed and synthesized. This was accomplished through the heteroannelation of purines, for...
8.
Husseiny E, Abulkhair H, El-Hddad S, Osama N, El-Zoghbi M
Future Med Chem
. 2023 Aug;
15(14):1213-1232.
PMID: 37584185
A fragment-based design and synthesis of three novel series of aminopyridone-linked benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was implemented. All synthesized compounds were submitted to National Cancer...
9.
Al-Karmalawy A, Rashed M, Sharaky M, Abulkhair H, Hammouda M, Tawfik H, et al.
Eur J Med Chem
. 2023 Jul;
259:115661.
PMID: 37482023
Although the great effectiveness of doxorubicin (Dox) in the treatment of many types of tumors, it showed limited effectiveness against the head and neck squamous cell carcinoma (HNSCC) subtype which...
10.
El-Kalyoubi S, Elbaramawi S, Eissa A, Al-Ageeli E, Hobani Y, El-Sharkawy A, et al.
Future Med Chem
. 2023 Jun;
15(11):937-958.
PMID: 37381751
The previously reported dual histone deacetylase type II (HDAC II) / topoisomerase type I (Topo I) inhibitors suffer pharmacokinetic limitations because of their huge molecular weights. We report the design...