Hakimuddin Sojar
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Explore the profile of Hakimuddin Sojar including associated specialties, affiliations and a list of published articles.
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74
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Recent Articles
1.
Sojar H, Baron S, Hicar M
bioRxiv
. 2024 Jul;
PMID: 38979252
Background: We have previously isolated a highly mutated VH1-02 antibody termed group C 76-Q13-6F5 (6F5) that targets a conformational epitope on gp41. 6F5 has the capacity to mediate Ab dependent...
2.
DeCotes D, Baron S, Hoffman J, Garrett M, Sojar H, Hicar M
Arch Virol
. 2022 Jul;
167(11):2193-2201.
PMID: 35871426
Identifying epitope targets by studying the native antibody (Ab) response can identify potential novel vaccine constructs. Studies suggest that long-term non-progressor (LTNP) subjects have inherent immune mechanisms that help to...
3.
Wrotniak B, Garrett M, Baron S, Sojar H, Shon A, Asiago-Reddy E, et al.
Vaccine
. 2022 Jun;
40(31):4174-4181.
PMID: 35688727
In studies on monoclonal IgG antibodies (mAbs) from long-term non-progressors (LTNPs), our laboratory has previously described highly mutated Abs against a complex conformational epitope with contributions from both gp41 the...
4.
Sojar H, Baron S, Sullivan J, Garrett M, van Haaren M, Hoffman J, et al.
J Virol
. 2019 Jun;
93(17).
PMID: 31217246
Previous studies in our laboratory characterized a panel of highly mutated HIV-specific conformational epitope-targeting antibodies (Abs) from a panel of HIV-infected long-term nonprogressors (LTNPs). Despite binding HIV envelope protein and...
5.
Smith M, Hoffman J, Sojar H, Aalinkeel R, Hsiao C, Hicar M
Curr HIV Res
. 2019 Mar;
16(6):404-415.
PMID: 30836922
Background: During HIV infection, fusion of the viral and cellular membranes is dependent on folding of the gp41 trimer into a six-helix bundle. Fusion inhibitors, such as the antiretroviral Enfuvirtide...
6.
Hicar M, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, et al.
PLoS One
. 2016 Jul;
11(7):e0158861.
PMID: 27411063
Numerous broadly neutralizing antibodies (Abs) target epitopes that are formed or enhanced during mature HIV envelope formation (i.e. quaternary epitopes). Generally, it is thought that Env epitopes that induce broadly...
7.
Hicar M, Chen X, Kalams S, Sojar H, Landucci G, Forthal D, et al.
Mol Immunol
. 2016 Jan;
70:94-103.
PMID: 26748387
Neutralizing antibodies (Abs) are thought to be a critical component of an appropriate HIV vaccine response. It has been proposed that Abs recognizing conformationally dependent quaternary epitopes on the HIV...
8.
Boehm T, Sojar H, Denardin E
Cell Immunol
. 2010 Mar;
263(1):41-8.
PMID: 20303075
In this paper, we aim to characterize fibrinogen-IgG interactions, and explore how fibrinogen alters IgG-mediated phagocytosis. Using enzyme-linked binding assays, we found that fibrinogen binding to IgG is optimized for...
9.
Hajishengallis G, Sojar H, Genco R, Denardin E
Immunol Invest
. 2004 Jun;
33(2):157-72.
PMID: 15195695
Toll-like receptors (TLRs) and other pattern-recognition receptors (PRRs) of the innate immune system form functional receptor complexes that recognize and respond to pathogen-associated molecular patterns (PAMPs). Porphyromonas gingivalis is an...