Paul Spearman
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Explore the profile of Paul Spearman including associated specialties, affiliations and a list of published articles.
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116
Citations
2901
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Recent Articles
1.
Candor K, Ding L, Balchand S, Hammonds J, Spearman P
PLoS Pathog
. 2025 Mar;
21(3):e1012564.
PMID: 40067817
HIV-1 particles are captured by the immunoglobulin superfamily member Siglec-1 on the surface of macrophages and dendritic cells, leading to particle internalization and facilitating trans-infection of CD4+ T cells. HIV-1-infected...
2.
El Sahly H, Anderson E, Jackson L, Neuzil K, Atmar R, Bernstein D, et al.
Vaccine
. 2025 Jan;
47:126689.
PMID: 39756216
Introduction: Pandemic influenza vaccine development focuses on the hemagglutinin (HA) antigen for potency and immunogenicity. Antibody responses targeting the neuraminidase (NA) antigen, or the HA stalk domain have been implicated...
3.
Rostad C, Yildirim I, Kao C, Yi J, Kamidani S, Peters E, et al.
NPJ Vaccines
. 2024 Dec;
9(1):255.
PMID: 39715748
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple...
4.
Temple H, Donnelly B, Mohanty S, Mowery S, Poling H, Pasula R, et al.
Am J Physiol Gastrointest Liver Physiol
. 2024 Jun;
327(2):G267-G283.
PMID: 38860860
Biliary atresia (BA) is the leading indication for pediatric liver transplantation. Rhesus rotavirus (RRV)-induced murine BA develops an obstructive cholangiopathy that mirrors the human disease. We have previously demonstrated the...
5.
Beavis A, Dienger-Stambaugh K, Briggs K, Chen Z, Abraham M, Spearman P, et al.
Vaccine
. 2024 Mar;
42(9):2347-2356.
PMID: 38443277
Human immunodeficiency virus (HIV) infects and depletes CD4 T-cells, resulting in Acquired Immunodeficiency Syndrome (AIDS) and death. Despite numerous clinical trials, there is no licensed HIV vaccine. The HIV envelope...
6.
Miner M, deCamp A, Grunenberg N, De Rosa S, Fiore-Gartland A, Bar K, et al.
EBioMedicine
. 2024 Feb;
100:104987.
PMID: 38306894
Background: Elicitation of broad immune responses is understood to be required for an efficacious preventative HIV vaccine. This Phase 1 randomized controlled trial evaluated whether administration of vaccine antigens separated...
7.
Lerner G, Ding L, Candor K, Spearman P
bioRxiv
. 2024 Jan;
PMID: 38168173
The HIV-1 envelope glycoprotein (Env) is incorporated into particles during assembly on the plasma membrane (PM). Env initially reaches the PM through the secretory pathway, after which it is rapidly...
8.
Spearman P, Jin H, Knopp K, Xiao P, Gingerich M, Kidd J, et al.
Sci Adv
. 2023 Oct;
9(43):eadj7611.
PMID: 37878713
Respiratory syncytial virus (RSV) can lead to serious disease in infants, and no approved RSV vaccine is available for infants. This first in-human clinical trial evaluated a single dose of...
9.
Lerner G, Ding L, Spearman P
J Virol
. 2023 Oct;
97(10):e0063123.
PMID: 37796124
The HIV-1 envelope glycoprotein (Env) is an essential component of the virus and has an exceedingly long cytoplasmic tail (CT). Previous studies have suggested that trafficking signals in the CT...
10.
Ware J, McElhinney K, Latham T, Lane A, Dienger-Stambaugh K, Hildeman D, et al.
Breastfeed Med
. 2023 Aug;
18(8):612-620.
PMID: 37615566
Pregnant and lactating women were not included in the initial large vaccine clinical trials for SARS-CoV-2 (COVID) infection. Delineating the antibody titers in serum and breast milk of lactating women...