Hajime Niwa
Overview
Explore the profile of Hajime Niwa including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
419
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Recent Articles
1.
Niwa H, Miyauchi-Nanri Y, Okumoto K, Mukai S, Noi K, Ogura T, et al.
J Biochem
. 2018 Sep;
164(6):437-447.
PMID: 30204880
A newly isolated binding protein of peroxisomal targeting signal type 2 (PTS2) receptor Pex7, termed P7BP2, is transported into peroxisomes by binding to the longer isoform of Pex5p, Pex5pL, via...
2.
Yoshida Y, Niwa H, Honsho M, Itoyama A, Fujiki Y
Biol Open
. 2015 Apr;
4(6):710-21.
PMID: 25910939
Pex11p family proteins are key players in peroxisomal fission, but their molecular mechanisms remains mostly unknown. In the present study, overexpression of Pex11pβ caused substantial vesiculation of peroxisomes in mammalian...
3.
Noguchi M, Honsho M, Abe Y, Toyama R, Niwa H, Sato Y, et al.
J Hum Genet
. 2014 May;
59(7):387-92.
PMID: 24849933
Rhizomelic chondrodysplasia punctata (RCDP) is an autosomal recessive disorder due to the deficiency in ether lipid synthesis. RCDP type 1, the most prominent type, is caused by the dysfunction of...
4.
Yeung H, Forster A, Bebeacua C, Niwa H, Ewens C, McKeown C, et al.
Open Biol
. 2014 Mar;
4:130142.
PMID: 24598262
The type II AAA+ protein p97 is involved in numerous cellular activities, including endoplasmic reticulum-associated degradation, transcription activation, membrane fusion and cell-cycle control. These activities are at least in part...
5.
Niwa H, Ewens C, Tsang C, Yeung H, Zhang X, Freemont P
J Biol Chem
. 2012 Jan;
287(11):8561-70.
PMID: 22270372
p97/valosin-containing protein (VCP) is a type II ATPase associated with various cellular activities that forms a homohexamer with each protomer containing an N-terminal domain (N-domain); two ATPase domains, D1 and...
6.
Yeung H, Kloppsteck P, Niwa H, Isaacson R, Matthews S, Zhang X, et al.
Biochem Soc Trans
. 2008 Jan;
36(Pt 1):62-7.
PMID: 18208387
The AAA (ATPase associated with various cellular activities) p97 [also known as VCP (valosin-containing protein)] participates in numerous biological activities and is an essential component of the ubiquitin signalling pathway....
7.
Suno R, Niwa H, Tsuchiya D, Zhang X, Yoshida M, Morikawa K
Mol Cell
. 2006 Jun;
22(5):575-85.
PMID: 16762831
An ATP-dependent protease, FtsH, digests misassembled membrane proteins in order to maintain membrane integrity and digests short-lived soluble proteins in order to control their cellular regulation. This enzyme has an...
8.
Rappas M, Schumacher J, Niwa H, Buck M, Zhang X
J Mol Biol
. 2006 Jan;
357(2):481-92.
PMID: 16430918
Bacterial enhancer-binding proteins (EBP) activate transcription by hydrolyzing ATP to restructure the sigma(54)-RNA polymerase-promoter complex. We compare six high resolution structures (<2.1 A) of the AAA(+) domain of EBP phage...
9.
Rappas M, Schumacher J, Beuron F, Niwa H, Bordes P, Wigneshweraraj S, et al.
Science
. 2005 Mar;
307(5717):1972-5.
PMID: 15790859
Activators of bacterial sigma54-RNA polymerase holoenzyme are mechanochemical proteins that use adenosine triphosphate (ATP) hydrolysis to activate transcription. We have determined by cryogenic electron microscopy (cryo-EM) a 20 angstrom resolution...
10.
Rappas M, Niwa H, Zhang X
Curr Protein Pept Sci
. 2004 Apr;
5(2):89-105.
PMID: 15078220
ATPases are important molecular machines that convert the chemical energies stored in ATP to mechanical actions within the cell. ATPases are among the most abundant proteins with diverse functions involved...