Haithem Barbour
Overview
Explore the profile of Haithem Barbour including associated specialties, affiliations and a list of published articles.
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13
Citations
557
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Recent Articles
1.
Barbour H, Nkwe N, Estavoyer B, Messmer C, Gushul-Leclaire M, Villot R, et al.
iScience
. 2023 May;
26(5):106276.
PMID: 37168555
Ubiquitination is an important post-translational modification (PTM) that regulates a large spectrum of cellular processes in eukaryotes. Abnormalities in ubiquitin signaling underlie numerous human pathologies including cancer and neurodegeneration. Much...
2.
Uriarte M, Nkwe N, Tremblay R, Ahmed O, Messmer C, Mashtalir N, et al.
Nat Commun
. 2021 Dec;
12(1):6984.
PMID: 34848715
Eukaryotic cells have evolved highly orchestrated protein catabolic machineries responsible for the timely and selective disposal of proteins and organelles, thereby ensuring amino acid recycling. However, how protein degradation is...
3.
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos
Novelli F, Bononi A, Wang Q, Bai F, Patergnani S, Kricek F, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(48).
PMID: 34815344
Carriers of heterozygous germline mutations () are affected by the "BAP1 cancer syndrome." Although they can develop almost any cancer type, they are unusually susceptible to asbestos carcinogenesis and mesothelioma....
4.
Li L, Guturi K, Gautreau B, Patel P, Saad A, Morii M, et al.
J Clin Invest
. 2021 Jul;
131(13).
PMID: 34196309
No abstract available.
5.
Patel P, Abraham K, Guturi K, Halaby M, Khan Z, Palomero L, et al.
J Clin Invest
. 2021 Feb;
131(3).
PMID: 33529165
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to...
6.
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
Barbour H, Daou S, Hendzel M, Affar E
Nat Commun
. 2020 Nov;
11(1):5947.
PMID: 33230107
Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed...
7.
Nkwe N, Daou S, Uriarte M, Gagnon J, Iannantuono N, Barbour H, et al.
J Cell Sci
. 2020 Feb;
133(4).
PMID: 32005696
USP16 (also known as UBP-M) has emerged as a histone H2AK119 deubiquitylase (DUB) implicated in the regulation of chromatin-associated processes and cell cycle progression. Despite this, available evidence suggests that...
8.
Masclef L, Maxime U, Ahmed O, Nkwe N, Barbour H, Iannantuono N, et al.
J Vis Exp
. 2019 Aug;
(149).
PMID: 31403616
Ubiquitination is a post-translational modification that plays important roles in various signaling pathways and is notably involved in the coordination of chromatin function and DNA-associated processes. This modification involves a...
9.
Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Nkwe N, et al.
Nat Commun
. 2018 Oct;
9(1):4385.
PMID: 30349006
The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. ASXLs and...
10.
Li L, Guturi K, Gautreau B, Patel P, Saad A, Morii M, et al.
J Clin Invest
. 2018 Sep;
128(10):4525-4542.
PMID: 30222135
The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and...