Hadassa Hirschfield
Overview
Explore the profile of Hadassa Hirschfield including associated specialties, affiliations and a list of published articles.
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8
Citations
284
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Recent Articles
1.
Crouchet E, Bandiera S, Fujiwara N, Li S, El Saghire H, Fernandez-Vaquero M, et al.
Nat Commun
. 2021 Sep;
12(1):5525.
PMID: 34535664
Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple and...
2.
Sojoodi M, Wei L, Erstad D, Yamada S, Fujii T, Hirschfield H, et al.
Cancer Prev Res (Phila)
. 2020 Apr;
13(6):497-508.
PMID: 32253266
Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment options. HCC arises from chronically inflamed and damaged liver tissue; therefore, chemoprevention may be a useful strategy...
3.
Ishikawa G, Fujiwara N, Hirschfield H, Varricchio L, Hoshida Y, Barosi G, et al.
Exp Hematol
. 2019 Nov;
79:16-25.e3.
PMID: 31678370
Megakaryocytes have been implicated in the micro-environmental abnormalities associated with fibrosis and hematopoietic failure in the bone marrow (BM) of primary myelofibrosis (PMF) patients, the Philadelphia-negative myeloproliferative neoplasm (MPN) associated...
4.
Rodriguez-Bravo V, Pippa R, Song W, Carceles-Cordon M, Dominguez-Andres A, Fujiwara N, et al.
Cell
. 2018 Aug;
174(5):1200-1215.e20.
PMID: 30100187
Nuclear pore complexes (NPCs) regulate nuclear-cytoplasmic transport, transcription, and genome integrity in eukaryotic cells. However, their functional roles in cancer remain poorly understood. We interrogated the evolutionary transcriptomic landscape of...
5.
Fujiwara N, Nakagawa H, Enooku K, Kudo Y, Hayata Y, Nakatsuka T, et al.
Gut
. 2018 Feb;
67(8):1493-1504.
PMID: 29437870
Objective: Metabolic reprogramming of tumour cells that allows for adaptation to their local environment is a hallmark of cancer. Interestingly, obesity-driven and non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) mouse models...
6.
Hirschfield H, Bian C, Higashi T, Nakagawa S, Zeleke T, Nair V, et al.
Exp Mol Med
. 2018 Jan;
50(1):e419.
PMID: 29303513
Tractable experimental model that accounts for inter-tumor molecular heterogeneity is a key element of anti-cancer drug development. Hepatocellular carcinoma is known to exhibit highly heterogeneous molecular aberrations across the tumors,...
7.
Deshmukh M, Nakagawa S, Higashi T, Vincek A, Venkatesh A, Ruiz de Galarreta M, et al.
Nanomedicine
. 2017 Nov;
14(2):317-325.
PMID: 29157977
Safety is prerequisite for preventive medicine, but non-toxic agents are generally ineffective as clinical chemoprevention. Here we propose a strategy overcoming this challenge by delivering molecular-targeted agent specifically to the...
8.
Taouli B, Hoshida Y, Kakite S, Chen X, Tan P, Sun X, et al.
Eur Radiol
. 2017 Apr;
27(11):4472-4481.
PMID: 28439654
Objectives: In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). Methods: Thirty-eight patients (M/F 30/8, mean age 61 years)...