Bryan C Fuchs
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Explore the profile of Bryan C Fuchs including associated specialties, affiliations and a list of published articles.
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98
Citations
3575
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Recent Articles
1.
Wang Y, Leaker B, Qiao G, Sojoodi M, Eissa I, Epstein E, et al.
Hepatol Commun
. 2024 Oct;
8(11).
PMID: 39445861
Background: Considering the lack of successful treatment options and poor prognosis for cirrhosis and cirrhosis-induced HCC, new platforms to investigate antifibrotic therapies are urgently needed. Precision-cut liver slice (PCLS) is...
2.
Blount K, Papazyan R, Ferdyan N, Srinivasan K, Gonzalez C, Shannon W, et al.
J Infect Dis
. 2024 Aug;
PMID: 39172632
Background: Microbiota-based treatments are effective in preventing recurrent Clostridioides difficile infection (rCDI). Fecal microbiota, live-jslm (REBYOTA®; RBL, previously RBX2660) was shown to prevent rCDI in a phase 3, randomized, double-blinded...
3.
Tang H, Abston E, Sojoodi M, Wang Y, Erstad D, Lin Z, et al.
JTCVS Open
. 2024 May;
18:306-321.
PMID: 38690408
Objective: Previous studies have demonstrated synergistic antitumor effects of angiotensin system inhibition (ASI) combined with cisplatin therapy in pancreatic cancer. This study examines whether or not synergistic antitumor effects occur...
4.
Wang Y, Leaker B, Qiao G, Sojoodi M, Eissa I, Epstein E, et al.
bioRxiv
. 2023 Nov;
PMID: 37961334
Background: Precision-Cut Liver Slices (PCLS) are an culture model developed to study hepatic drug metabolism. One of the main benefits of this model is that it retains the structure and...
5.
Stalewski J, Shih A, Papazyan R, Ramirez J, Ibanez G, Hsiao P, et al.
J Pharmacol Exp Ther
. 2023 May;
386(1):35-44.
PMID: 37142444
Inflammatory bowel disease (IBD) is characterized by chronic mucosal inflammation of the gastrointestinal tract and is associated with extracellular acidification of mucosal tissue. Several extracellular pH-sensing receptors, including G protein-coupled...
6.
Chen Y, Waghorn P, Rosales I, Arora G, Erstad D, Rotile N, et al.
J Am Soc Nephrol
. 2023 Apr;
34(7):1159-1165.
PMID: 37094382
Background: In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. We hypothesized that MRI with the allysine-targeted probe Gd-oxyamine (OA) could be...
7.
Papazyan R, Ferdyan N, Srinivasan K, Gonzalez C, Shannon W, Blount K, et al.
Microorganisms
. 2023 Jan;
11(1).
PMID: 36677428
Microbiome-based therapeutics are increasingly evaluated as a strategy to reduce recurrent infection (rCDI), with proposed mechanisms including restoration of the microbiota and microbiota-mediated functions, such as bile acid (BA) metabolism....
8.
Roehlen N, Saviano A, El Saghire H, Crouchet E, Nehme Z, Del Zompo F, et al.
Sci Transl Med
. 2022 Dec;
14(676):eabj4221.
PMID: 36542691
Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need...
9.
Zhang G, Wang Y, Fuchs B, Guo W, Drum D, Erstad D, et al.
Front Oncol
. 2022 Aug;
12:913736.
PMID: 35912209
Background: Sorafenib, a kinase inhibitor, is a standard treatment for advanced hepatocellular carcinoma (HCC) but provides only a limited survival benefit. Disulfiram (DSF), a drug for treating alcoholism and a...
10.
Crouchet E, Li S, Sojoodi M, Bandiera S, Fujiwara N, El Saghire H, et al.
JCI Insight
. 2022 Jul;
7(13).
PMID: 35801591
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients, for which chemopreventive strategies are lacking. Recently, we developed a simple human cell-based system modeling a clinical prognostic...