H Michael Shepard
Overview
Explore the profile of H Michael Shepard including associated specialties, affiliations and a list of published articles.
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36
Citations
1378
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Recent Articles
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Chen B, Salas J, Trias A, Perez Rodriguez A, Tsang J, Guemes M, et al.
Immunology
. 2022 Aug;
168(1):152-169.
PMID: 35986643
Multiple sclerosis (MS) is an autoimmune disease driven by lymphocyte activation against myelin autoantigens in the central nervous system leading to demyelination and neurodegeneration. The deoxyribonucleoside salvage pathway with the...
3.
Wang L, Londono L, Cowell J, Saatci O, Aras M, Ersan P, et al.
Cancer Res
. 2021 Apr;
81(12):3319-3332.
PMID: 33863778
Extracellular adenosine in tumors can suppress immune responses and promote tumor growth. Adenosine deaminase 2 (ADA2) converts adenosine into inosine. The role of ADA2 in cancer and whether it can...
4.
He Y, Schreiber K, Wolf S, Wen F, Steentoft C, Zerweck J, et al.
JCI Insight
. 2019 Dec;
4(23).
PMID: 31801912
No abstract available.
5.
Zhao C, Thompson B, Chen K, Gao F, Blouw B, Marella M, et al.
Oncotarget
. 2019 Nov;
10(61):6561-6576.
PMID: 31762938
Hyaluronan accumulation in the tumor microenvironment is associated with poor prognosis in several solid human cancers. To understand the role of stromal hyaluronan in tumor progression, we engineered 3T3HAS3, a...
6.
He Y, Schreiber K, Wolf S, Wen F, Steentoft C, Zerweck J, et al.
JCI Insight
. 2019 Nov;
4(21).
PMID: 31672936
Human cancer cells were eradicated by adoptive transfer of T cells transduced with a chimeric antigen receptor (CAR) made from an antibody (237Ab) that is highly specific for the murine...
7.
Shepard H
Cell
. 2019 Sep;
179(1):27-32.
PMID: 31519309
Receiving the Lasker award for Clinical Medical Research is a staggering event. Perhaps equally staggering is the fact that as many as 2 million women worldwide have now been treated...
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Li X, Shepard H, Cowell J, Zhao C, Osgood R, Rosengren S, et al.
Clin Cancer Res
. 2018 Aug;
24(19):4798-4807.
PMID: 30084839
The tumor microenvironment (TME) evolves to support tumor progression. One marker of more aggressive malignancy is hyaluronan (HA) accumulation. Here, we characterize biological and physical changes associated with HA-accumulating (HA-high)...
10.
Marella M, Jadin L, Keller G, Sugarman B, Frost G, Shepard H
Glycobiology
. 2018 Jul;
28(12):958-967.
PMID: 30007349
Modification of hyaluronan (HA) accumulation has been shown to play a key role in regulating inflammatory processes linked to the progression of multiple sclerosis (MS). The aim of this study...