H M Verheul
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Explore the profile of H M Verheul including associated specialties, affiliations and a list of published articles.
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20
Citations
580
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Recent Articles
11.
Bom J, Verheul H, Hoekman K, Pinedo H
Ned Tijdschr Geneeskd
. 2000 Feb;
144(6):258-63.
PMID: 10687017
Coagulation disorders occur often in cancer patients. Thrombosis or embolism may be the first sign of an underlying malignancy. In addition, subclinical coagulation disturbances have been found in the blood...
12.
Verheul H, Hoekman K, Lupu F, Broxterman H, van der Valk P, Kakkar A, et al.
Clin Cancer Res
. 2000 Feb;
6(1):166-71.
PMID: 10656446
Angiogenesis and activated blood coagulation are involved in tumor growth and metastasis. Although some have suggested that activation of coagulation in tumors is not linked to activation of platelets, no...
13.
Verheul H, Panigrahy D, Flynn E, Pinedo H, DAmato R
Pediatr Res
. 1999 Dec;
46(5):562-5.
PMID: 10541319
Kasabach-Merritt Syndrome (KMS) is seen in children with large vascular tumors. KMS is characterized by very low platelet counts and a consumption of coagulation factors causing life-threatening complications. It has...
14.
Verheul H, Bom J, Hoekman K, Pinedo H
Ned Tijdschr Geneeskd
. 1999 Aug;
143(30):1549-55.
PMID: 10443279
Angiogenesis is the process of new vessel formation from pre-existing vasculature. In preclinical as well as clinical research it has been demonstrated that tumour growth and formation of metastases are...
15.
Verheul H, Panigrahy D, Yuan J, DAmato R
Br J Cancer
. 1999 Jul;
79(1):114-8.
PMID: 10408702
Neovascularization facilitates tumour growth and metastasis formation. In our laboratory, we attempt to identify clinically available oral efficacious drugs for antiangiogenic activity. Here, we report which non-steroidal anti-inflammatory drugs (NSAIDs)...
16.
Luykx-de Bakker S, Verheul H, de Gruijl T, Pinedo H
Ann Oncol
. 1999 Mar;
10(2):155-60.
PMID: 10093683
Background: Neoadjuvant chemotherapy is increasingly applied in patients with locally advanced cancers of many tumour types. Usually three cycles of chemotherapy are administered to reduce the tumour size prior to...
17.
Pinedo H, Verheul H, DAmato R, Folkman J
Lancet
. 1998 Dec;
352(9142):1775-7.
PMID: 9848370
Preclinical and clinical research show that tumour growth is dependent on angiogenesis. Activation of the coagulation cascade is commonly found in patients with cancer. We propose that platelets contribute to...
18.
Verheul H, Hoekman K, Eekman C, Folman C, Broxterman H, Pinedo H
Clin Cancer Res
. 1998 Nov;
3(12 Pt 1):2187-90.
PMID: 9815613
In animal models, growth of tumors and their metastases is dependent on factors that stimulate vessel formation (angiogenesis). Most clinical studies confirm the importance of angiogenesis for cancer growth in...
19.
Feller N, Hoekman K, Kuiper C, Linn S, Verheul H, Wolthers B, et al.
Clin Cancer Res
. 1997 Mar;
3(3):389-94.
PMID: 9815696
We describe a patient with a metastasized adrenocortical cancer who exhibited excessive production of both glucocorticoids and mineralocorticoids combined with suppressed androgen production. Unusual steroid metabolites found in the patient's...
20.
Effects of chemotherapy on pathologic and biologic characteristics of locally advanced breast cancer
Honkoop A, Pinedo H, de Jong J, Verheul H, Linn S, Hoekman K, et al.
Am J Clin Pathol
. 1997 Feb;
107(2):211-8.
PMID: 9024070
In 42 patients with locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiation therapy, the effects of chemotherapy on tumor architecture, morphometric nuclear and nucleolar characteristics,...