H Kalthoff
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Explore the profile of H Kalthoff including associated specialties, affiliations and a list of published articles.
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124
Citations
2821
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Recent Articles
1.
Boger C, Kruger S, Behrens H, Bock S, Haag J, Kalthoff H, et al.
Ann Oncol
. 2017 Apr;
28(5):1005-1014.
PMID: 28453696
Background: Recent whole-genome sequencing identified four molecular subtypes of gastric cancer (GC), of which the subgroup of Epstein-Barr virus-associated GC (EBVaGC) showed a significant enrichment of PIK3CA mutations. We here...
2.
Zaccagnino A, Pilarsky C, Tawfik D, Sebens S, Trauzold A, Novak I, et al.
Eur Biophys J
. 2016 Sep;
45(7):749-763.
PMID: 27652669
The altered expression and/or activity of ion channels and transporters (transportome) have been associated with malignant behavior of cancer cells and were proposed to be a hallmark of cancer. However,...
3.
Lascano V, Hahne M, Papon L, Cameron K, Roeder C, Schafmayer C, et al.
Oncogenesis
. 2015 Jan;
4:e136.
PMID: 25622308
We have previously shown that the tumor necrosis factor family member a proliferation-inducing ligand (APRIL) enhances intestinal tumor growth in various preclinical tumor models. Here, we have investigated whether APRIL...
4.
Bertsch U, Roder C, Kalthoff H, Trauzold A
Cell Death Dis
. 2014 Aug;
5:e1390.
PMID: 25165876
Localized in the plasma membrane, death domain-containing TNF-related apoptosis-inducing ligand (TRAIL) receptors, TRAIL-R1 and TRAIL-R2, induce apoptosis and non-apoptotic signaling when crosslinked by the ligand TRAIL or by agonistic receptor-specific...
5.
Eisenach P, Soeth E, Roder C, Kloppel G, Tepel J, Kalthoff H, et al.
Br J Cancer
. 2013 Jul;
109(3):694-703.
PMID: 23839495
Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Improvements in the understanding of its molecular mechanism and the characterisation of CRC-specific biomarkers facilitating early detection...
6.
Arlt A, Schafer H, Kalthoff H
Oncogenesis
. 2013 Apr;
1:e35.
PMID: 23552468
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies, with an overall life expectancy of 6 months. Despite considerable advances in the understanding of the molecular mechanisms involved in...
7.
Lascano V, Zabalegui L, Cameron K, Guadagnoli M, Jansen M, Burggraaf M, et al.
Cell Death Differ
. 2012 Jun;
19(11):1826-35.
PMID: 22705846
The tumor necrosis factor (TNF) family member APRIL (A proliferation inducing ligand) is a disease promoter in B-cell malignancies. APRIL has also been associated with a wide range of solid...
8.
Castro F, Forsti A, Buch S, Kalthoff H, Krauss C, Bauer M, et al.
Eur J Cancer
. 2011 Jan;
47(8):1203-10.
PMID: 21239167
Background: Clinicopathologic stage is still the main parameter to evaluate the prognosis of newly diagnosed colorectal cancer (CRC) patients. Although molecular markers have been suggested for follow up of treated...
9.
Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, et al.
Cell Death Differ
. 2010 Apr;
17(9):1435-47.
PMID: 20379197
Constitutively active PI3K catalytic subunit alpha (PIK3CA) interfered with apoptosis induction downstream of death receptor-signaling complex formation allowing robust caspase-8 activation without triggering the execution steps of apoptosis. In mutant...
10.
Arlt A, Bauer I, Schafmayer C, Tepel J, Muerkoster S, Brosch M, et al.
Oncogene
. 2009 Sep;
28(45):3983-96.
PMID: 19734940
An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this...