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H Kalthoff

Explore the profile of H Kalthoff including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 124
Citations 2821
Followers 0
Related Specialties
Oncology
Molecular Biology
Gastroenterology
Top 10 Co-Authors
D Henne-Bruns
W Schmiegel
B Kremer
C Roder
H Juhl
C Roeder
H Ungefroren
B Sipos
A Trauzold
W H Schmiegel
Published In
Oncogene
Br J Cancer
Cancer Res
Klin Monbl Augenheilkd
Int J Cancer
Affiliations
Soon will be listed here.
Recent Articles
11.
Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma
Ruckert F, Hennig M, Petraki C, Wehrum D, Distler M, Denz A, et al.
Br J Cancer . 2008 Oct; 99(9):1484-92. PMID: 18854834
Kallikreins play an important role in tumour microenvironment and as cancer biomarkers in different cancer entities. Previous studies suggested an upregulation of KLK10 and KLK6 in pancreatic ductal adenocarcinoma (PDAC)....
12.
Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo
Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, et al.
Gut . 2008 Jan; 57(6):799-806. PMID: 18203806
Background: Pancreatic ductal adenocarcinomas (PDACs) are highly resistant to treatment due to changes in various signalling pathways. CK1 isoforms play important regulatory roles in these pathways. Aims: We analysed the...
13.
Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition
Wrobel P, Shojaei H, Schittek B, Gieseler F, Wollenberg B, Kalthoff H, et al.
Scand J Immunol . 2007 Jul; 66(2-3):320-8. PMID: 17635809
Human gammadelta T cells expressing a V gamma 9V delta 2 T-cell receptor (TCR) kill various tumour cells including autologous tumours. In addition to TCR-dependent recognition, activation of NKG2D-positive gammadelta...
14.
Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function
Schniewind B, Groth S, Muerkoster S, Sipos B, Schafer H, Kalthoff H, et al.
Oncogene . 2007 Feb; 26(33):4850-62. PMID: 17297450
In the present study, we have analysed the effects of transforming growth factor-beta (TGF-beta) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in...
15.
Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells
Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grutzmann R, et al.
Br J Cancer . 2006 Dec; 96(1):73-81. PMID: 17164759
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease and one of the cancer entities with the lowest life expectancy. Beside surgical therapy, no effective therapeutic options are available yet. Here,...
16.
Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway
Baril P, Gangeswaran R, Mahon P, Caulee K, Kocher H, Harada T, et al.
Oncogene . 2006 Oct; 26(14):2082-94. PMID: 17043657
Pancreatic ductal adenocarcinoma is a devastating disease, characterized by a rapid progression and poor treatment response. Using gene expression profiling of pancreatic cancer tissues, we previously identified periostin as a...
17.
TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma
Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D, et al.
Oncogene . 2006 Jun; 25(56):7434-9. PMID: 16751802
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable attention for its potential use in tumor therapy, as some recombinant variants of this ligand induce apoptosis in tumor cells without...
18.
Significant growth inhibition of orthotopic pancreatic ductal adenocarcinoma by CpG oligonucleotides in immunodeficient mice
Tepel J, Dagvadorj O, Kapischke M, Sipos B, Leins A, Kremer B, et al.
Int J Colorectal Dis . 2005 Sep; 21(4):365-72. PMID: 16133009
Background/aims: The high rate of local recurrence after radical resection of pancreatic ductal adenocarcinoma fosters intensive efforts to develop new approaches for adjuvant treatment. Antisense and modified oligodeoxynucleotides (ODNs) have...
19.
Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression
Kurdow R, Schniewind B, Zoefelt S, Boenicke L, Boehle A, Dohrmann P, et al.
Langenbecks Arch Surg . 2005 Feb; 390(3):243-8. PMID: 15726400
Background: This study assesses the chemotherapeutic drug gemcitabine in the human non-small cell lung cancer (NSCLC) cell line KNS62 in relation to the CD95-induced apoptotic pathway, and the role of...
20.
Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
Bentele M, Lavrik I, Ulrich M, Stosser S, Heermann D, Kalthoff H, et al.
J Cell Biol . 2004 Sep; 166(6):839-51. PMID: 15364960
Mathematical modeling is required for understanding the complex behavior of large signal transduction networks. Previous attempts to model signal transduction pathways were often limited to small systems or based on...