H H Szeto
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Explore the profile of H H Szeto including associated specialties, affiliations and a list of published articles.
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87
Citations
625
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Recent Articles
1.
Szeto H, James L, Atkinson A
Clin Pharmacol Ther
. 2014 Nov;
96(6):629-33.
PMID: 25399706
Mitochondrial medicine is an evolving discipline whose importance derives from the central function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive oxygen species, and cell death by necrosis...
2.
Szeto H, Birk A
Clin Pharmacol Ther
. 2014 Sep;
96(6):672-83.
PMID: 25188726
The mitochondrial electron transport chain (ETC) plays a central role in energy generation in the cell. Mitochondrial dysfunctions diminish adenosine triphosphate (ATP) production and result in insufficient energy to maintain...
3.
Birk A, Chao W, Bracken C, Warren J, Szeto H
Br J Pharmacol
. 2013 Oct;
171(8):2017-28.
PMID: 24134698
Background And Purpose: Cardiolipin plays an important role in mitochondrial respiration and cardiolipin peroxidation is associated with age-related diseases. Hydrophobic interactions between cytochrome c and cardiolipin converts cytochrome c from...
4.
Derick S, Cheng L, Voirol M, Stoev S, Giacomini M, Wo N, et al.
Endocrinology
. 2002 Nov;
143(12):4655-64.
PMID: 12446593
To date, there are no vasopressin (VP) agonists that exhibit a high affinity and selectivity for the VP V1b receptor with respect to the V1a, V2, and oxytocin receptors. In...
5.
Resensitization of blood pressure response to mu-opioid peptide agonists after acute desensitization
Szeto H, Soong Y, Wu D, Fasolo J
Anesth Analg
. 2001 Aug;
93(3):581-6.
PMID: 11524321
IV administration of mu-opioid peptide agonists (DAMGO, DALDA, and [Dmt(1)]DALDA) results in a transient, naloxone-sensitive, increase in blood pressure in awake sheep. Despite significant differences in pharmacokinetics, these blood pressure...
6.
Szeto H, Lovelace J, Fridland G, Soong Y, Fasolo J, Wu D, et al.
J Pharmacol Exp Ther
. 2001 Jun;
298(1):57-61.
PMID: 11408525
Recent evidence suggests that highly selective mu-opioid agonists may provide good analgesia with less development of tolerance and dependence. H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and H-Dmt-D-Arg-Phe-Lys-NH2 ([Dmt1]DALDA) were found to display high binding...
7.
Shimoyama M, Shimoyama N, Zhao G, Schiller P, Szeto H
J Pharmacol Exp Ther
. 2001 Mar;
297(1):364-71.
PMID: 11259564
DALDA (H-Tyr-D-Arg-Phe-Lys-NH(2)) and [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2)) (Dmt = 2',6'-dimethyltyrosine) are potent and highly selective mu-opioid agonists (K(i)(delta)/K(i)(mu) > 10,000 and K(i)(kappa)/K(i)(mu) > 100). Both peptides carry a 3+ charge at physiological...
8.
Cheng P, Birk A, Gershengorn M, Szeto H
Neuroendocrinology
. 2000 Mar;
71(3):170-6.
PMID: 10729788
Dynorphin (Dyn) peptides were previously shown to increase plasma corticotropin (ACTH) in the ovine fetus, but the site of its action remains unclear. In the present study, Dyn A(1-17) was...
9.
Omoniyi A, Kett A, Wu D, Soong Y, Clapp 3rd J, Szeto H
J Cardiovasc Pharmacol
. 2000 Feb;
35(2):269-74.
PMID: 10672860
We previously reported that i.v. DAMGO (Tyr-D-Ala-Gly-NMePhe-Gly-ol), a selective mu-opioid agonist, causes an increase in blood pressure with no change in heart rate in unanesthetized sheep and subsequently demonstrated that...
10.
Arndt M, Wu D, Soong Y, Szeto H
Peptides
. 1999 Aug;
20(4):465-70.
PMID: 10458516
This study was undertaken to examine the cardiovascular effects of nociceptin/Orphanin FQ (OFQ). Nociceptin/OFQ (10-300 nmol/kg, IV) stimulates an increase in mean blood pressure (MBP) and heart rate (HR) in...