H D Colby
Overview
Explore the profile of H D Colby including associated specialties, affiliations and a list of published articles.
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139
Citations
290
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Recent Articles
1.
Colby H, Nowak D, Longhurst P, Zhang X, Hayes J, Voigt J
Pharmacology
. 2001 May;
62(4):229-33.
PMID: 11360000
Previous investigations demonstrated that CYP2D16 was expressed at high levels in guinea pig adrenal microsomes. The studies presented here were done to determine whether adrenal metabolism of bufuralol (BUF), a...
2.
Burczynski J, Southard S, Hayes J, Longhurst P, Colby H
Free Radic Biol Med
. 2001 Apr;
30(9):1029-35.
PMID: 11316583
Studies were done to evaluate the effects of alpha-tocopherol deficiency in rats on the fatty acid composition and sensitivity to lipid peroxidation (LP) of mitochondria and microsomes from adrenal glands,...
3.
Suppression of lipid peroxidation in adrenal microsomes following ACTH administration to guinea pigs
Burczynski J, Hayes J, Voigt J, Longhurst P, Colby H
J Endocrinol
. 2001 Feb;
168(2):333-8.
PMID: 11182771
Previous studies demonstrated high levels of lipid peroxidation (LP) in the guinea pig adrenal cortex. The present studies were done to determine if adrenal LP activity was influenced by ACTH,...
4.
Yuan B, Tchao R, Voigt J, Colby H
Drug Metab Dispos
. 2001 Feb;
29(2):194-9.
PMID: 11159811
CYP2D16 is expressed at high levels in the zona reticularis (ZR) of guinea pig adrenal glands and contributes to adrenal metabolism of xenobiotics. Studies were done to evaluate the effects...
5.
Colby H, Huang Y, Jiang Q, Voigt J
Pharmacology
. 2000 Aug;
61(2):78-82.
PMID: 10940780
Prior studies revealed an apparent bimodal distribution of adrenal xenobiotic-metabolizing activities in outbred guinea pigs. High activities were characteristic of most animals but a minority had very low rates of...
6.
Burczynski J, Hayes J, Longhurst P, Colby H
Free Radic Biol Med
. 1999 May;
26(7-8):987-91.
PMID: 10232843
Previous reports have noted high levels of lipid peroxidation (LP) in vitro in a variety of adrenocortical preparations. However, we have observed that susceptibility to adrenal LP seems to vary...
7.
Feingold I, Longhurst P, Colby H
Free Radic Biol Med
. 1999 Apr;
26(5-6):633-8.
PMID: 10218651
Studies were done to determine the effects of ACTH treatment on adrenal alpha-tocopherol (alpha-T) concentrations in female rats. Administration of dexamethasone (DEX) to inhibit endogenous ACTH secretion increased whole adrenal...
8.
Yuan B, Tchao R, Funae Y, Voigt J, Colby H
Mol Cell Endocrinol
. 1999 Feb;
146(1-2):129-36.
PMID: 10022770
Experiments were done to determine the actions of ACTH on the morphologic and functional characteristics of the zona fasciculata (ZF) and zona reticularis (ZR) in the guinea pig adrenal cortex....
9.
Huang Y, Jiang Q, DeBolt K, Voigt J, Colby H
J Steroid Biochem Mol Biol
. 1998 Jun;
64(5-6):305-11.
PMID: 9618032
We recently reported that CYP2D16, a xenobiotic-metabolizing P450 isozyme, was expressed at higher levels in adrenal microsomes from inbred Strain 13 guinea pigs than in those from outbred English Short...
10.
Soltis M, Colby H
Pharmacology
. 1998 Feb;
56(1):51-6.
PMID: 9467188
Effects of 1-aminobenzotriazole (ABT) on testicular steroid metabolism were evaluated in rats. Administration of ABT to adult male rats caused dose-dependent decreases in testicular microsomal and mitochondrial cytochrome P450 concentrations....