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H Blocker

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Articles 63
Citations 11694
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Recent Articles
1.
Wade C, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F, et al.
Science . 2009 Nov; 326(5954):865-7. PMID: 19892987
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few...
2.
Lin L, Flisikowski K, Schwarzenbacher H, Scharfe M, Severitt S, Blocker H, et al.
Anim Genet . 2009 Oct; 41(2):203-7. PMID: 19793316
AMP-activated protein kinase (AMPK), known as a key regulator of cellular energy homeostasis, plays an important role in regulation of glucose and lipid metabolism, and protein synthesis in mammals. The...
3.
Keller B, Ohnesorg T, Mindnich R, Gloeckner C, Breitling R, Scharfe M, et al.
Mol Cell Endocrinol . 2005 Dec; 248(1-2):168-71. PMID: 16337734
17Beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key enzyme of 17beta-estradiol biosynthesis, and in rodents is additionally involved in testosterone biosynthesis. The human HSD17B1 gene, located on chromosome 17q12-21, is...
4.
Watanabe H, Fujiyama A, Hattori M, Taylor T, Toyoda A, Kuroki Y, et al.
Nature . 2004 May; 429(6990):382-8. PMID: 15164055
Human-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of...
5.
Humphray S, Oliver K, HUNT A, Plumb R, Loveland J, Howe K, et al.
Nature . 2004 May; 429(6990):369-74. PMID: 15164053
Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of...
6.
Lander E, Linton L, Birren B, Nusbaum C, Zody M, Baldwin J, et al.
Nature . 2001 Mar; 409(6822):860-921. PMID: 11237011
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely...
7.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al.
Genome Res . 2001 Mar; 11(3):422-35. PMID: 11230166
With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs,...
8.
Silakowski B, Nordsiek G, Kunze B, Blocker H, Muller R
Chem Biol . 2001 Feb; 8(1):59-69. PMID: 11182319
Background: Myxobacteria have been well established as a potent source for natural products with biological activity. They produce a considerable variety of compounds which represent typical polyketide structures with incorporated...
9.
Salanoubat M, Lemcke K, Rieger M, Ansorge W, Unseld M, Fartmann B, et al.
Nature . 2000 Dec; 408(6814):820-2. PMID: 11130713
Arabidopsis thaliana is an important model system for plant biologists. In 1996 an international collaboration (the Arabidopsis Genome Initiative) was formed to sequence the whole genome of Arabidopsis and in...
10.
Silakowski B, Kunze B, Nordsiek G, Blocker H, Hofle G, Muller R
Eur J Biochem . 2000 Oct; 267(21):6476-85. PMID: 11029592
The biosynthetic gene cluster of the myxochelin-type iron chelator was cloned from Stigmatella aurantiaca Sg a15 and characterized. This catecholate siderophore was only known from two other myxobacteria. The biosynthetic...