H Apeler
Overview
Explore the profile of H Apeler including associated specialties, affiliations and a list of published articles.
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10
Citations
262
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Recent Articles
1.
Gu J, Ramsey P, Evans V, Tang L, Apeler H, Leong L, et al.
Haemophilia
. 2014 Jan;
20(4):593-600.
PMID: 24471985
Patients with haemophilia (PWH) are usually monitored by the one-stage activated partial thromboplastin time (aPTT) factor VIII (FVIII) assay. Different aPTT activators may affect clotting time (CT) and FVIII:C levels...
2.
Brooks A, Sim D, Gritzan U, Patel C, Blasko E, Feldman R, et al.
J Thromb Haemost
. 2013 May;
11(9):1699-706.
PMID: 23692404
Background: The rapid clearance of factor IX (FIX) necessitates frequent intravenous administration to achieve effective prophylaxis for patients with hemophilia B. Subcutaneous administration would be a preferred route of administration...
3.
Pohlscheidt M, Langer U, Minuth T, Bodeker B, Apeler H, Horlein H, et al.
Vaccine
. 2008 Feb;
26(12):1552-65.
PMID: 18295380
For the production of a chemically inactivated Parapoxvirus ovis (PPVO), an adherent bovine kidney cell line was cultivated on Cytodex-3 microcarriers in suspension culture. The inactivated and purified virus particles...
4.
Kast R, Schirok H, Figueroa-Perez S, Mittendorf J, Gnoth M, Apeler H, et al.
Br J Pharmacol
. 2007 Oct;
152(7):1070-80.
PMID: 17934515
Background And Purpose: Rho-kinase (ROCK) has been implicated in the pathophysiology of altered vasoregulation leading to hypertension. Here we describe the pharmacological characterization of a potent, highly selective and orally...
5.
Becker E, Apeler H, Gerzer R, Minuth T, Pleiss U, Schmidt P, et al.
BMC Pharmacol
. 2002 Jan;
1:13.
PMID: 11801189
Background: The most important receptor for nitric oxide is the soluble guanylate cyclase (sGC), a heme containing heterodimer. Recently, a pyrazolopyridine derivative BAY 41-2272, structurally related to YC-1, was identified...
6.
Stasch J, Becker E, Apeler H, Dembowsky K, Feurer A, Gerzer R, et al.
Nature
. 2001 Mar;
410(6825):212-5.
PMID: 11242081
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research in the field of NO appears to have followed a straightforward path, and...
7.
Domingues H, Peters J, Schneider K, Apeler H, Sebald W, Oschkinat H, et al.
J Biotechnol
. 2001 Feb;
84(3):217-30.
PMID: 11164263
Interleukin-4 (IL-4) is a multifunctional cytokine that plays an important role in the regulation of various immune responses. However, the development of IL-4 or IL-4 variants into potential therapeutic drugs...
8.
Hoenicka M, Becker E, Apeler H, Sirichoke T, Schroder H, Gerzer R, et al.
J Mol Med (Berl)
. 1999 Feb;
77(1):14-23.
PMID: 9930922
Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide, a messenger molecule with multiple clinical implications. Understanding the activation of sGC is an important step for establishing new...
9.
Apeler H, Gottschalk U, Guntermann D, Hansen J, Massen J, Schmidt E, et al.
Eur J Biochem
. 1997 Aug;
247(3):890-5.
PMID: 9288912
An attractive target for anti-herpes chemotherapy is the herpes simplex virus 1 (HSV-1) protease encoded by the UL26 gene. Studies with HSV-1 strains that harbour mutations in the protease gene...
10.
Yalkinoglu A, Spreyer P, Bechem M, Apeler H, Wohlfeil S
J Recept Signal Transduct Res
. 1995 Jan;
15(1-4):117-30.
PMID: 8903936
The rat vascular smooth muscle cell (VSMC) line A10 (ATCC CRL 1476) was stably transfected with a human c-fos promoter-driven luciferase reporter gene to monitor thrombin receptor activation and subsequent...