Gyula Timinszky
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Explore the profile of Gyula Timinszky including associated specialties, affiliations and a list of published articles.
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35
Citations
1791
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Recent Articles
1.
Dukic B, Ruppert Z, Toth M, Hunya A, Czibula A, Biro P, et al.
Cells
. 2024 Jul;
13(13.
PMID: 38994992
Previous studies reported that a mild, non-protein-denaturing, fever-like temperature increase induced the unfolded protein response (UPR) in mammalian cells. Our dSTORM super-resolution microscopy experiments revealed that the master regulator of...
2.
Mamar H, Fajka-Boja R, Morocz M, Pinto Jurado E, Zentout S, Mihut A, et al.
Nucleic Acids Res
. 2024 Jun;
52(12):6994-7011.
PMID: 38828775
The clinical success of PARP1/2 inhibitors (PARPi) prompts the expansion of their applicability beyond homologous recombination deficiency. Here, we demonstrate that the loss of the accessory subunits of DNA polymerase...
3.
Pinto Jurado E, Smith R, Bigot N, Chapuis C, Timinszky G, Huet S
Mol Biol Cell
. 2024 Jan;
35(3):br7.
PMID: 38170578
ADP-ribosylation signaling orchestrates the recruitment of various repair actors and chromatin remodeling processes promoting access to lesions during the early stages of the DNA damage response. The chromatin remodeler complex...
4.
Groslambert J, Prokhorova E, Wondisford A, Tromans-Coia C, Giansanti C, Jansen J, et al.
Cell Rep
. 2023 Sep;
42(9):113113.
PMID: 37676774
The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that...
5.
Longarini E, Dauben H, Locatelli C, Wondisford A, Smith R, Muench C, et al.
Mol Cell
. 2023 Apr;
83(10):1743-1760.e11.
PMID: 37116497
PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence...
6.
Smith R, Zentout S, Rother M, Bigot N, Chapuis C, Mihut A, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(5):678-691.
PMID: 37106138
Poly(ADP-ribose) polymerase 1 (PARP1) activity is regulated by its co-factor histone poly(ADP-ribosylation) factor 1 (HPF1). The complex formed by HPF1 and PARP1 catalyzes ADP-ribosylation of serine residues of proteins near...
7.
Tromans-Coia C, Sanchi A, Moeller G, Timinszky G, Lopes M, Ahel I
Nucleic Acids Res
. 2021 Sep;
49(18):10477-10492.
PMID: 34508355
ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases. Recently, an...
8.
Luscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, et al.
FEBS J
. 2021 Jul;
289(23):7399-7410.
PMID: 34323016
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in...
9.
Juhasz S, Smith R, Schauer T, Spekhardt D, Mamar H, Zentout S, et al.
Sci Adv
. 2020 Dec;
6(51).
PMID: 33355125
Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the treatment of BRCA-deficient cancers, with treatments currently extending toward other homologous recombination defective tumors. In a genome-wide CRISPR knockout screen with olaparib,...
10.
Smith R, Lebeaupin T, Juhasz S, Chapuis C, DAugustin O, Dutertre S, et al.
Nucleic Acids Res
. 2019 Oct;
47(21):11250-11267.
PMID: 31566235
The addition of poly(ADP-ribose) (PAR) chains along the chromatin fiber due to PARP1 activity regulates the recruitment of multiple factors to sites of DNA damage. In this manuscript, we investigated...