Guy Perkins
Overview
Explore the profile of Guy Perkins including associated specialties, affiliations and a list of published articles.
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57
Citations
3319
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Recent Articles
1.
Dos Santos C, Cambraia A, Shrestha S, Cutler M, Cottam M, Perkins G, et al.
Nat Commun
. 2024 Oct;
15(1):9063.
PMID: 39433757
Caloric restriction (CR) can extend the organism life- and health-span by improving glucose homeostasis. How CR affects the structure-function of pancreatic beta cells remains unknown. We used single nucleus transcriptomics...
2.
Rocha A, Pai V, Perkins G, Chang T, Ma J, de Souza E, et al.
J Mol Biol
. 2024 Apr;
436(10):168559.
PMID: 38580077
Upstream open reading frames (uORFs) are cis-acting elements that can dynamically regulate the translation of downstream ORFs by suppressing downstream translation under basal conditions and, in some cases, increasing downstream...
3.
Lee J, Perez-Flores M, Park S, Kim H, Chen Y, Kang M, et al.
Nat Commun
. 2024 Jan;
15(1):526.
PMID: 38228630
The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals...
4.
Venkatraman K, Lee C, Garcia G, Mahapatra A, Milshteyn D, Perkins G, et al.
EMBO J
. 2023 Nov;
42(24):e114054.
PMID: 37933600
Cristae are high-curvature structures in the inner mitochondrial membrane (IMM) that are crucial for ATP production. While cristae-shaping proteins have been defined, analogous lipid-based mechanisms have yet to be elucidated....
5.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, et al.
Res Sq
. 2023 Oct;
PMID: 37790446
Caloric restriction (CR) extends organismal lifespan and health span by improving glucose homeostasis mechanisms. How CR affects organellar structure and function of pancreatic beta cells over the lifetime of the...
6.
Dos Santos C, Shrestha S, Cottam M, Perkins G, Lev-Ram V, Roy B, et al.
bioRxiv
. 2023 Sep;
PMID: 37662336
Caloric restriction (CR) extends organismal lifespan and health span by improving glucose homeostasis mechanisms. How CR affects organellar structure and function of pancreatic beta cells over the lifetime of the...
7.
Lee J, Perez-Flores M, Park S, Kim H, Chen Y, Kang M, et al.
Res Sq
. 2023 Jul;
PMID: 37502846
The inner ear is the hub where hair cells transduce sound, gravity, and head acceleration stimuli carried by neural codes to the brain. Of all the senses, hearing and balance,...
8.
Torten G, Fisher S, Linberg K, Luna G, Perkins G, Ellisman M, et al.
J Neurosci
. 2023 Jul;
43(30):5468-5482.
PMID: 37414561
The rod photoreceptor synapse is the first synapse of dim-light vision and one of the most complex in the mammalian CNS. The components of its unique structure, a presynaptic ribbon...
9.
Venkatraman K, Lee C, Garcia G, Mahapatra A, Milshteyn D, Perkins G, et al.
bioRxiv
. 2023 Mar;
PMID: 36993370
Cristae are high curvature structures in the inner mitochondrial membrane (IMM) that are crucial for ATP production. While cristae-shaping proteins have been defined, analogous mechanisms for lipids have yet to...
10.
Marks de Chabris N, Sabir S, Perkins G, Cheng H, Ellisman M, Pamenter M
Comp Biochem Physiol A Mol Integr Physiol
. 2022 Nov;
276:111343.
PMID: 36379380
Hypoxia poses a significant energetic challenge and most species exhibit metabolic remodelling when exposed to prolonged hypoxia. One component of this remodelling is mitochondrial biogenesis/mitophagy, which alter mitochondrial abundance and...