Guy Hughes
Overview
Explore the profile of Guy Hughes including associated specialties, affiliations and a list of published articles.
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12
Citations
2578
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Recent Articles
1.
Wang X, Su J, Ding J, Han S, Ma W, Luo H, et al.
Drug Des Devel Ther
. 2016 Nov;
10:3449-3457.
PMID: 27799744
Objective: Ocular hypertension is an important risk factor for glaucoma. The purpose of this study was to investigate the gliotoxic effects of α-aminoadipic acid (AAA) in a rat model of...
2.
Chen Y, Hughes G, Chen X, Qian S, Cao W, Wang L, et al.
Invest Ophthalmol Vis Sci
. 2015 Feb;
56(4):2595-600.
PMID: 25711633
Purpose: We investigated the association of genetic factors with primary open angle glaucoma (POAG), including high tension glaucoma (HTG) and normal tension glaucoma (NTG), in a Han Chinese population. Methods:...
3.
Chen Y, Chen X, Wang L, Hughes G, Qian S, Sun X
Invest Ophthalmol Vis Sci
. 2014 May;
55(6):3797-802.
PMID: 24854855
Purpose: To investigate the association of PLEKHA7 and COL11A1 with primary angle closure glaucoma, as well as acute and chronic subphenotype, in a Han Chinese population. Methods: A total of...
4.
Fritsche L, Chen W, Schu M, Yaspan B, Yu Y, Thorleifsson G, et al.
Nat Genet
. 2013 Mar;
45(4):433-9, 439e1-2.
PMID: 23455636
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide...
5.
Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, et al.
Mol Cell
. 2012 Nov;
49(2):359-367.
PMID: 23177740
The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life. Although chronological age has been...
6.
Shaw P, Zhang L, Zhang M, Du H, Zhao L, Lee C, et al.
Proc Natl Acad Sci U S A
. 2012 Aug;
109(34):13757-62.
PMID: 22875704
The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the...
7.
Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, et al.
J Biol Chem
. 2011 Dec;
287(14):11469-80.
PMID: 22199362
Very long chain polyunsaturated fatty acid (VLC-PUFA)-containing glycerophospholipids are highly enriched in the retina; however, details regarding the specific synthesis and function of these highly unusual retinal glycerophospholipids are lacking....
8.
Zhang L, Lim S, Du H, Zhang M, Kozak I, Hannum G, et al.
J Biol Chem
. 2011 Nov;
287(2):1520-6.
PMID: 22049084
Genome-wide association study (GWAS) has identified genetic variants in the promoter region of the high temperature requirement factor A1 (HTRA1) gene associated with age-related macular degeneration (AMD). As a secreted...
9.
Rosenberg M, ORyan L, Hughes G, Zhao Z, Aleksandrov L, Riordan J, et al.
J Biol Chem
. 2011 Sep;
286(49):42647-42654.
PMID: 21931164
Cystic fibrosis affects about 1 in 2500 live births and involves loss of transmembrane chloride flux due to a lack of a membrane protein channel termed the cystic fibrosis transmembrane...
10.
Sommer J, Estrada J, Collins E, Bedell M, Alexander C, Yang Z, et al.
Br J Ophthalmol
. 2011 Aug;
95(12):1749-54.
PMID: 21873315
Background: Truncation mutations in the elongation of very long chain fatty acids-4 (AF277094, MIM #605512) (ELOVL4) gene cause Stargardt-like macular dystrophy type 3 (STGD3). Mice expressing truncated ELOVL4 develop rapid...