Gus R Rosania
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Explore the profile of Gus R Rosania including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
LaLone V, Fawaz M, Morales-Mercado J, Mourao M, Snyder C, Kim S, et al.
Analyst
. 2019 May;
144(12):3790-3799.
PMID: 31116195
Herein we report the development of a cytometric analysis platform for measuring the contents of individual cells in absolute (picogram) scales; this study represents the first report of Raman-based quantitation...
12.
Hong X, Rzeczycki P, Keswani R, Murashov M, Fan Z, Deng C, et al.
Sci Rep
. 2019 Apr;
9(1):5702.
PMID: 30952950
Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as well...
13.
Murashov M, Diaz-Espinosa J, LaLone V, Tan J, Laza R, Wang X, et al.
Pharmaceutics
. 2018 Nov;
10(4).
PMID: 30453628
Clofazimine (CFZ) is a broad spectrum antimycobacterial agent recommended by the World Health Organization as a first line treatment for leprosy and second line treatment for multidrug resistant tuberculosis. Oral...
14.
Rzeczycki P, Woldemichael T, Willmer A, Murashov M, Baik J, Keswani R, et al.
Pharm Res
. 2018 Nov;
36(1):12.
PMID: 30421091
Purpose: Clofazimine (CFZ) is an FDA-approved, poorly soluble small molecule drug that precipitates as crystal-like drug inclusions (CLDIs) which accumulate in acidic cytoplasmic organelles of macrophages. In this study, we...
15.
Rzeczycki P, Yoon G, Keswani R, Sud S, Baik J, Murashov M, et al.
Pharm Res
. 2018 Nov;
36(1):3.
PMID: 30406478
Purpose: Drug-induced liver injuries (DILI) comprise a significant proportion of adverse drug reactions leading to hospitalizations and death. One frequent DILI is granulomatous inflammation from exposure to harmful metabolites that...
16.
LaLone V, Mourao M, Standiford T, Raghavendran K, Shedden K, Stringer K, et al.
Pharm Res
. 2018 Nov;
36(1):2.
PMID: 30402713
Purpose: To improve cytometric phenotyping abilities and better understand cell populations with high interindividual variability, a novel Raman-based microanalysis was developed to characterize macrophages on the basis of chemical composition,...
17.
Woldemichael T, Keswani R, Rzeczycki P, Murashov M, LaLone V, Gregorka B, et al.
Sci Rep
. 2018 Feb;
8(1):2934.
PMID: 29440773
Weakly basic, poorly soluble chemical agents could be exploited as building blocks for constructing sophisticated molecular devices inside the cells of living organisms. Here, using experimental and computational approaches, we...
18.
Woldemichael T, Rosania G
PLoS One
. 2017 Nov;
12(11):e0187627.
PMID: 29117253
Many weakly basic, lipophilic drugs accumulate in lysosomes and exert complex, pleiotropic effects on organelle structure and function. Thus, modeling how perturbations of lysosomal physiology affect the maintenance of lysosomal...
19.
Murashov M, LaLone V, Rzeczycki P, Keswani R, Yoon G, Sud S, et al.
J Invest Dermatol
. 2017 Oct;
138(3):697-703.
PMID: 29042210
Clofazimine is a weakly basic, Food and Drug Administration-approved antibiotic recommended by the World Health Organization to treat leprosy and multi-drug-resistant tuberculosis. Upon prolonged treatment, clofazimine extensively bioaccumulates and precipitates...
20.
Rzeczycki P, Yoon G, Keswani R, Sud S, Stringer K, Rosania G
Biomed Opt Express
. 2017 Mar;
8(2):860-872.
PMID: 28270989
Following prolonged administration, certain orally bioavailable but poorly soluble small molecule drugs are prone to precipitate out and form crystal-like drug inclusions (CLDIs) within the cells of living organisms. In...