Guoxun Wang
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Explore the profile of Guoxun Wang including associated specialties, affiliations and a list of published articles.
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12
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1014
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Recent Articles
1.
Song J, Zhang L, Moon S, Fang A, Wang G, Gheshm N, et al.
Sci Adv
. 2025 Feb;
11(9):eadu7985.
PMID: 40020060
Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored. Here, we...
2.
Zhang J, Wang G, Ma J, Duan Y, Sharma S, Oladejo S, et al.
Sci Immunol
. 2024 Sep;
9(99):eadk7387.
PMID: 39331726
The intestinal mucosal surface is directly exposed to daily fluctuations in food and microbes driven by 24-hour light and feeding cycles. Intestinal epithelial tuft cells are key sentinels that surveil...
3.
Wang G, Zhang D, Orchard R, Hancks D, Reese T
bioRxiv
. 2023 Mar;
PMID: 36993770
Non-enveloped viruses require cell lysis to release new virions from infected cells, suggesting that these viruses require mechanisms to induce cell death. Noroviruses are one such group of viruses, but...
4.
Wang G, Zhang D, Orchard R, Hancks D, Reese T
Nature
. 2023 Mar;
616(7955):152-158.
PMID: 36991121
Non-enveloped viruses require cell lysis to release new virions from infected cells, suggesting that these viruses require mechanisms to induce cell death. Noroviruses are one such group of viruses, but...
5.
Tao L, Dryden P, Lowe A, Wang G, Achuthkumar A, Chang T, et al.
Microbiol Spectr
. 2023 Jan;
:e0233722.
PMID: 36715509
Peroxisome proliferator activated receptor (PPAR) agonists are commonly used to treat metabolic disorders in humans because they regulate fatty acid oxidation and cholesterol metabolism. In addition to their roles in...
6.
Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson L, et al.
Nat Nanotechnol
. 2022 May;
17(7):777-787.
PMID: 35551240
Genome editing holds great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of CRISPR/Cas to solid tumours for efficient cancer therapy...
7.
Wang G, Zarek C, Chang T, Tao L, Lowe A, Reese T
J Virol
. 2021 Feb;
95(8).
PMID: 33536178
Gammaherpesviruses, such as Epstein-Barr virus (EBV), Kaposi's sarcoma associated virus (KSHV), and murine γ-herpesvirus 68 (MHV68), establish latent infection in B cells, macrophages, and non-lymphoid cells, and can induce both...
8.
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, et al.
Elife
. 2020 Sep;
9.
PMID: 32886065
Reactive oxygen species (ROS) are by-products of cellular respiration that can promote oxidative stress and damage cellular proteins and lipids. One canonical role of ROS is to defend the cell...
9.
Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, et al.
Science
. 2019 Apr;
364(6435).
PMID: 30948527
Nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen effectors to trigger plant immunity. Biochemical mechanisms underlying plant NLR activation have until now remained poorly understood. We reconstituted an active complex containing...
10.
Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, et al.
Science
. 2019 Apr;
364(6435).
PMID: 30948526
Pathogen recognition by nucleotide-binding (NB), leucine-rich repeat (LRR) receptors (NLRs) plays roles in plant immunity. The pv. effector AvrAC uridylylates the PBL2 kinase, and the latter (PBL2) acts as a...