Guangsheng Pei
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Explore the profile of Guangsheng Pei including associated specialties, affiliations and a list of published articles.
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Articles
77
Citations
881
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Recent Articles
11.
Wang R, Song S, Qin J, Yoshimura K, Peng F, Chu Y, et al.
Cancer Cell
. 2023 Jul;
41(8):1407-1426.e9.
PMID: 37419119
Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma (GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell profiling of precancerous lesions, localized and metastatic GACs, identifying alterations in...
12.
Chu Y, Dai E, Li Y, Han G, Pei G, Ingram D, et al.
Nat Med
. 2023 May;
29(6):1550-1562.
PMID: 37248301
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 transcriptomes...
13.
Sahu U, Mullarkey M, Pei G, Zhao Z, Hong B, Kaur B
Mol Ther Oncolytics
. 2023 Apr;
29:30-41.
PMID: 37114074
Longstanding evidence implicate glioma stem-like cells as the main drivers contributing toward glioblastoma (GBM) therapy resistance and tumor recurrence. Although oncolytic herpes simplex virus (oHSV) viral therapy is a promising...
14.
Hong B, Sahu U, Mullarkey M, Hong E, Pei G, Yan Y, et al.
J Immunother Cancer
. 2023 Feb;
11(2).
PMID: 36796878
Background: Mammalian cells have developed multiple intracellular mechanisms to defend against viral infections. These include RNA-activated protein kinase (PKR), cyclic GMP-AMP synthase and stimulation of interferon genes (cGAS-STING) and toll-like...
15.
Sopariwala D, Rios A, Pei G, Roy A, Tomaz da Silva M, Thi Thu Nguyen H, et al.
FASEB J
. 2022 Dec;
37(2):e22727.
PMID: 36583689
Transcriptional determinants in the skeletal muscle that govern exercise capacity, while poorly defined, could provide molecular insights into how exercise improves fitness. Here, we have elucidated the role of nuclear...
16.
Zhang B, Jia P, Wang J, Pei G, Wang C, Pei S, et al.
Mol Oncol
. 2022 Dec;
17(4):564-581.
PMID: 36495164
The incidence of bladder cancer and patient survival vary greatly among different populations, but the influence of the associated molecular features and evolutionary processes on its clinical treatment and prognostication...
17.
Nie L, Wang C, Liu X, Teng H, Li S, Huang M, et al.
Genes Dev
. 2022 Oct;
36(17-18):1016-1030.
PMID: 36302555
Deubiquitylating enzymes (DUBs) remove ubiquitin chains from proteins and regulate protein stability and function. USP7 is one of the most extensively studied DUBs, since USP7 has several well-known substrates important...
18.
Liu W, Jia J, Dai Y, Chen W, Pei G, Yan Q, et al.
Innovation (Camb)
. 2022 Jul;
3(5):100289.
PMID: 35879967
Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis and immune response is vital for developing therapies. Single-cell RNA sequencing has been applied to delineate the cellular heterogeneity of...
19.
Feng X, Tang M, Dede M, Su D, Pei G, Jiang D, et al.
Sci Adv
. 2022 May;
8(19):eabm6638.
PMID: 35559673
Exploiting cancer vulnerabilities is critical for the discovery of anticancer drugs. However, tumor suppressors cannot be directly targeted because of their loss of function. To uncover specific vulnerabilities for cells...
20.
Pei G, Yan F, Simon L, Dai Y, Jia P, Zhao Z
Genomics Proteomics Bioinformatics
. 2022 Apr;
21(2):370-384.
PMID: 35470070
Single-cell RNA sequencing (scRNA-seq) is revolutionizing the study of complex and dynamic cellular mechanisms. However, cell type annotation remains a main challenge as it largely relies on a priori knowledge...