Guang-Zhi Shan
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Explore the profile of Guang-Zhi Shan including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
51
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Recent Articles
1.
Zhu Z, Qiu X, Wu S, Liu Y, Zhao T, Sun Z, et al.
Molecules
. 2020 Dec;
26(1).
PMID: 33374387
The novel coronavirus disease (2019-nCoV) has been affecting global health since the end of 2019, and there is no sign that the epidemic is abating. Targeting the interaction between the...
2.
Zhong Z, Zhang D, Peng Z, Li Y, Shan G, Zuo L, et al.
Eur J Med Chem
. 2013 Sep;
69:32-43.
PMID: 23999140
A series of novel (5-oxazolyl)phenyl amine derivatives were synthesized and their antiviral activities against the hepatitis C virus (HCV) and the coxsackie virus B3 (CVB3) and B6 (CVB6) were evaluated...
3.
Li Y, Gao L, Li K, Meng S, Zhu J, Li D, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2012 Dec;
912:43-9.
PMID: 23261821
A LC-MS/MS method for determining the concentration of the small molecule Hsp90 inhibitor, GM-AMPL, has been developed and validated in rat plasma to support preclinical development. 17-[2-(morpholine-4-yl)ethyl]amino-17-demethoxygeldanamycin (GM-AMPL) and the...
4.
Hao L, Li Y, He W, Wang H, Shan G, Jiang J, et al.
Eur J Med Chem
. 2012 Jul;
55:117-24.
PMID: 22824205
The influenza virus is a persistent cause of mortality and morbidity on an annual basis and thus presents itself as an important target for pharmaceutical investigation. In this work, substituted...
5.
Li C, Shan G, Fan B, Tao P, Zhao L, Jiang J, et al.
Yao Xue Xue Bao
. 2011 Sep;
46(6):683-7.
PMID: 21882529
In order to find antiviral compounds with novel structures, geldanamycin and lamivudine with different antiviral mechanisms were conjunctively synthesized to acquire a new compound TC-GM, and the antiviral activity of...
6.
Shan G, Peng Z, Li Y, Li D, Li Y, Meng S, et al.
J Antibiot (Tokyo)
. 2010 Dec;
64(2):177-82.
PMID: 21179047
A novel class of geldanamycin (GA) derivatives as hepatitis C virus (HCV) replication inhibitors has been synthesized and their anti-HCV activities were evaluated in GS4.3 HCV replicon cells. Most of...
7.
Li Y, Shan G, Peng Z, Zhu J, Meng S, Zhang T, et al.
Antivir Chem Chemother
. 2010 Aug;
20(6):259-68.
PMID: 20710066
Background: Previous studies have suggested that geldanamycin (GA) inhibits the replication of several viruses in vitro. Here, we aimed to synthesize and evaluate the antiviral activity of 17-amino-17-demethoxygeldanamycin derivatives. Methods:...