Guan-Yu Xiao
Overview
Explore the profile of Guan-Yu Xiao including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
300
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Recent Articles
1.
Tan X, Xiao G, Banerjee P, Wang S, Kurie J
J Clin Invest
. 2024 Sep;
134(17).
PMID: 39225096
No abstract available.
2.
Tan X, Wang S, Xiao G, Wu C, Liu X, Zhou B, et al.
J Clin Invest
. 2024 Apr;
134(12).
PMID: 38662435
Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon...
3.
Xiao G, Tan X, Rodriguez B, Gibbons D, Wang S, Wu C, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(28):e2220276120.
PMID: 37406091
Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance, and metastasis in epithelial malignancies. However, the way in which EMT orchestrates disparate biological processes remains unclear. Here, we identify an EMT-activated vesicular...
4.
Tan X, Xiao G, Wang S, Shi L, Zhao Y, Liu X, et al.
J Clin Invest
. 2023 Feb;
133(7).
PMID: 36757799
Hypersecretory malignant cells underlie therapeutic resistance, metastasis, and poor clinical outcomes. However, the molecular basis for malignant hypersecretion remains obscure. Here, we showed that epithelial-mesenchymal transition (EMT) initiates exocytic and...
5.
Banerjee P, Xiao G, Tan X, Zheng V, Shi L, Rabassedas M, et al.
Nat Commun
. 2021 Nov;
12(1):6354.
PMID: 34732702
Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates motility and invasion. Dynamic assembly of focal adhesions and other actin-based...
6.
Uchikawa E, Chen Z, Xiao G, Zhang X, Bai X
Nat Commun
. 2021 Jul;
12(1):4074.
PMID: 34210960
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal cell development and motility. Aberrant activation of c-MET can lead to both tumors growth and...
7.
Tan X, Banerjee P, Shi L, Xiao G, Rodriguez B, Grzeskowiak C, et al.
Sci Adv
. 2021 Jun;
7(25).
PMID: 34144984
Cancer cells exhibit hyperactive secretory states that maintain cancer cell viability and remodel the tumor microenvironment. However, the oncogenic signals that heighten secretion remain unclear. Here, we show that p53...
8.
Xiao G, Schmid S
PLoS Biol
. 2020 Jul;
18(7):e3000778.
PMID: 32678845
The evolution of transformed cancer cells into metastatic tumors is, in part, driven by altered intracellular signaling downstream of receptor tyrosine kinases (RTKs). The surface levels and activity of RTKs...
9.
Xiao G, Mohanakrishnan A, Schmid S
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):E9570-E9579.
PMID: 30249660
Clathrin-mediated endocytosis (CME) regulates the uptake of cell-surface receptors as well as their downstream signaling activities. We recently reported that signaling can reciprocally regulate CME in cancer cells and that...
10.
Xiao G, Cheng C, Chiang Y, Cheng W, Liu I, Wu S
Sci Rep
. 2016 Mar;
6:23120.
PMID: 26979400
Chemotherapy (CTx)-induced premature ovarian failure (POF) in woman remains clinically irreversible. Amniotic fluid stem cells (AFSCs) have shown the potential to treat CTx-induced POF; however, the underlying mechanism is unclear....