Gretchen A Larusch
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Explore the profile of Gretchen A Larusch including associated specialties, affiliations and a list of published articles.
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8
Citations
341
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Recent Articles
1.
Desai A, Zhang Y, Park Y, Dawson D, Larusch G, Kasturi L, et al.
Haematologica
. 2018 Feb;
103(6):1054-1064.
PMID: 29472361
Hematopoietic stem cell transplantation following myeloablative chemotherapy is a curative treatment for many hematopoietic malignancies. However, profound granulocytopenia during the interval between transplantation and marrow recovery exposes recipients to risks...
2.
Zhang Y, Desai A, Yang S, Bae K, Antczak M, Fink S, et al.
Science
. 2015 Jun;
348(6240):aaa2340.
PMID: 26068857
Agents that promote tissue regeneration could be beneficial in a variety of clinical settings, such as stimulating recovery of the hematopoietic system after bone marrow transplantation. Prostaglandin PGE2, a lipid...
3.
Adams G, Stavrou E, Fang C, Merkulova A, Alaiti M, Nakajima K, et al.
Blood
. 2013 Jun;
122(8):1522-31.
PMID: 23744584
Prolylcarboxypeptidase (PRCP) is associated with leanness, hypertension, and thrombosis. PRCP-depleted mice have injured vessels with reduced Kruppel-like factor (KLF)2, KLF4, endothelial nitric oxide synthase (eNOS), and thrombomodulin. Does PRCP influence...
4.
Larusch G, Merkulova A, Mahdi F, Shariat-Madar Z, Sitrin R, Cines D, et al.
Am J Physiol Heart Circ Physiol
. 2013 May;
305(3):H305-20.
PMID: 23709605
How single-chain urokinase (ScuPA) mediates angiogenesis is incompletely understood. ScuPA (≥4 nM) induces phosphorylated (p)ERK1/2 (MAPK44 and MAPK42) and pAkt (Ser(473)) in umbilical vein and dermal microvascular endothelial cells. Activation...
5.
Adams G, Larusch G, Stavrou E, Zhou Y, Nieman M, Jacobs G, et al.
Blood
. 2011 Feb;
117(14):3929-37.
PMID: 21297000
Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt)...
6.
Larusch G, Mahdi F, Shariat-Madar Z, Adams G, Sitrin R, Zhang W, et al.
Blood
. 2010 Mar;
115(24):5111-20.
PMID: 20228268
Factor XII (FXII) and high molecular weight kininogen (HK) mutually block each other's binding to the urokinase plasminogen activator receptor (uPAR). We investigated if FXII stimulates cells by interacting with...
7.
Larusch G, Jackson M, Dunbar J, Warren R, Donner D, Mayo L
Cancer Res
. 2007 Jan;
67(2):450-4.
PMID: 17234751
Hdm2 is elevated in numerous types of malignancies and is thought to impede the function of wild-type p53. Reactivation of p53 by disrupting the association with Hdm2 was the impetus...
8.
Jackson M, Patt L, Larusch G, Donner D, Stark G, Mayo L
J Biol Chem
. 2006 Apr;
281(24):16814-20.
PMID: 16621805
Insulin-like growth factor (IGF)-I receptor activation leads to enhanced proliferation and cell survival via the MAP kinase and phosphatidylinositol 3-kinase-signaling pathways. Upon stimulation by IGF-I, the Hdm2 oncoprotein is phosphorylated...