Gregory N Adams
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Explore the profile of Gregory N Adams including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
283
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Recent Articles
1.
Maier C, Schadock I, Haber P, Wysocki J, Ye M, Kanwar Y, et al.
J Mol Med (Berl)
. 2017 Feb;
95(5):473-486.
PMID: 28160049
Key Message: Prolylcarboxypeptidase (PRCP) converts AngII to Ang (1-7) but only at an acidic pH. Global PRCP deficiency causes heart and kidney alterations and a moderate rise in BP. PRCP...
2.
Adams G, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, et al.
Cancer Res
. 2015 Aug;
75(19):4235-43.
PMID: 26238780
Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally important for primary tumor growth. Here, we report that colorectal adenocarcinoma represents one important exception whereby thrombin-mediated functions...
3.
Adams G, Stavrou E, Fang C, Merkulova A, Alaiti M, Nakajima K, et al.
Blood
. 2013 Jun;
122(8):1522-31.
PMID: 23744584
Prolylcarboxypeptidase (PRCP) is associated with leanness, hypertension, and thrombosis. PRCP-depleted mice have injured vessels with reduced Kruppel-like factor (KLF)2, KLF4, endothelial nitric oxide synthase (eNOS), and thrombomodulin. Does PRCP influence...
4.
Fang C, Stavrou E, Schmaier A, Grobe N, Morris M, Chen A, et al.
Blood
. 2013 Feb;
121(15):3023-32.
PMID: 23386129
Bradykinin B2 receptor-deleted mice (Bdkrb2(-/-)) have delayed carotid artery thrombosis times and prolonged tail bleeding time resulting from elevated angiotensin II (AngII) and angiotensin receptor 2 (AT2R) producing increased plasma...
5.
6.
Loyd C, Diaconu D, Fu W, Adams G, Brandt E, Knutsen D, et al.
Int J Clin Exp Pathol
. 2012 Feb;
5(1):1-11.
PMID: 22295141
VEGF and Angiopoietin (Ang)1 are growth factors that independently improve wound healing outcomes. Using a tet-repressible mouse model coupled with streptozotocin-induced diabetes, we examined wound healing in diabetic and nondiabetic...
7.
Bandyopadhyay S, Harris D, Adams G, Lause G, McHugh A, Tillmaand E, et al.
Mol Cell Biol
. 2012 Jan;
32(7):1202-13.
PMID: 22269951
The induction of proinflammatory proteins in stimulated endothelial cells (EC) requires activation of multiple transcription programs. The homeobox transcription factor HOXA9 has an important regulatory role in cytokine induction of...
8.
Adams G, Larusch G, Stavrou E, Zhou Y, Nieman M, Jacobs G, et al.
Blood
. 2011 Feb;
117(14):3929-37.
PMID: 21297000
Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt)...