Gregory M Shackleford
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Explore the profile of Gregory M Shackleford including associated specialties, affiliations and a list of published articles.
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15
Citations
422
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Recent Articles
1.
Tran H, Singh H, Guo W, Cambier L, Riggan L, Shackleford G, et al.
Front Oncol
. 2021 Jan;
10:563156.
PMID: 33425720
MYC family oncoproteins MYC, MYCN, and MYCL are deregulated in diverse cancers and via diverse mechanisms. Recent studies established a novel form of MYCN regulation in MYCN-overexpressing retinoblastoma and neuroblastoma...
2.
Pathania A, Ren X, Mahdi M, Shackleford G, Erdreich-Epstein A
Sci Rep
. 2019 Sep;
9(1):13902.
PMID: 31554835
G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas are the most common malignant...
3.
Shackleford G, Mahdi M, Moats R, Hawes D, Tran H, Finlay J, et al.
PLoS One
. 2019 Jan;
14(1):e0206394.
PMID: 30608927
Leptomeningeal metastasis remains a difficult clinical challenge. Some success has been achieved by direct administration of therapeutics into the cerebrospinal fluid (CSF) circumventing limitations imposed by the blood brain barrier....
4.
Xu J, Ren X, Pathania A, Fernandez G, Tran A, Zhang Y, et al.
Sci Rep
. 2017 Apr;
7(1):835.
PMID: 28400607
Phosphotyrosine Interaction Domain containing 1 (PID1; NYGGF4) inhibits growth of medulloblastoma, glioblastoma and atypical teratoid rhabdoid tumor cell lines. PID1 tumor mRNA levels are highly correlated with longer survival in...
5.
Shackleford G, Shi X, Swanson K, Mahdi M, Gonzalez-Gomez I, Asgharzadeh S, et al.
PLoS One
. 2016 Jun;
11(6):e0156907.
PMID: 27310018
Medulloblastomas are the most common malignant pediatric brain tumor and have been divided into four major molecular subgroups. Animal models that mimic the principal molecular aberrations of these subgroups will...
6.
Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson T, et al.
Clin Cancer Res
. 2013 Dec;
20(4):827-36.
PMID: 24300787
Purpose: We present here the first report of PID1 (Phosphotyrosine Interaction Domain containing 1; NYGGF4) in cancer. PID1 was identified in 2006 as a gene that modulates insulin signaling and...
7.
Long M, Huang S, Wu C, Shackleford G, Jong A
J Biomed Sci
. 2012 Feb;
19:19.
PMID: 22316086
Background: Cryptococcus neoformans has a predilection for central nervous system infection. C. neoformans traversal of the blood brain barrier, composed of human brain microvascular endothelial cells (HBMEC), is the crucial...
8.
Blavier L, Lazaryev A, Shi X, Dorey F, Shackleford G, DeClerck Y
Cancer Biol Ther
. 2010 Jun;
10(2):198-208.
PMID: 20534975
Matrix metalloproteinases (MMPs) play a well-defined role in later stages of tumor progression. However, there has been evidence that they also contribute to earlier stages of malignant transformation. The Wnt...
9.
Xiong G, Husseiny M, Song L, Erdreich-Epstein A, Shackleford G, Seeger R, et al.
Int J Cancer
. 2009 Oct;
126(11):2622-34.
PMID: 19824039
Although tumors express potentially immunogenic tumor-associated antigens (TAAs), cancer vaccines often fail because of inadequate antigen delivery and/or insufficient activation of innate immunity. Engineering nonpathogenic bacterial vectors to deliver TAAs...
10.
Jong A, Wu C, Prasadarao N, Kwon-Chung K, Chang Y, Ouyang Y, et al.
Cell Microbiol
. 2008 May;
10(9):1854-65.
PMID: 18489726
Pathogenic fungus Cryptococcus neoformans has a predilection for the central nervous system causing devastating meningoencephalitis. Traversal of C. neoformans across the blood-brain barrier (BBB) is a crucial step in the...