Greg Elgar
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Explore the profile of Greg Elgar including associated specialties, affiliations and a list of published articles.
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82
Citations
4426
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Recent Articles
1.
Nelan R, Mijuskovic M, Hughes M, Becq J, Kingsbury Z, Tsogka E, et al.
J Clin Pathol
. 2025 Mar;
PMID: 40032506
Aims: Whole-genome sequencing (WGS) is beginning to be applied to cancer samples in the clinical setting. This ideally requires high-quality, minimally degraded DNA of high tumour cell content, while retaining...
2.
Espejo Valle-Inclan J, De Noon S, Trevers K, Elrick H, van Belzen I, Zumalave S, et al.
Cell
. 2025 Jan;
188(2):352-370.e22.
PMID: 39814020
Osteosarcoma is the most common primary cancer of the bone, with a peak incidence in children and young adults. Using multi-region whole-genome sequencing, we find that chromothripsis is an ongoing...
3.
Basyuni S, Heskin L, Degasperi A, Black D, Koh G, Chmelova L, et al.
Nat Commun
. 2024 Sep;
15(1):7731.
PMID: 39231944
Whole genome sequencing (WGS) provides comprehensive, individualised cancer genomic information. However, routine tumour biopsies are formalin-fixed and paraffin-embedded (FFPE), damaging DNA, historically limiting their use in WGS. Here we analyse...
4.
Pei Y, Tanguy M, Giess A, Dixit A, Wilson L, Gibbons R, et al.
Genes (Basel)
. 2024 Jul;
15(7).
PMID: 39062704
The identification of structural variants (SVs) in genomic data represents an ongoing challenge because of difficulties in reliable SV calling leading to reduced sensitivity and specificity. We prepared high-quality DNA...
5.
Oakley J, Hill M, Giess A, Tanguy M, Elgar G
J Transl Med
. 2023 Nov;
21(1):825.
PMID: 37978513
Background: Causative genetic variants cannot yet be found for many disorders with a clear heritable component, including chronic fatigue disorders like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). These conditions may involve...
6.
Wei W, Schon K, Elgar G, Orioli A, Tanguy M, Giess A, et al.
Nature
. 2022 Oct;
611(7934):105-114.
PMID: 36198798
DNA transfer from cytoplasmic organelles to the cell nucleus is a legacy of the endosymbiotic event-the majority of nuclear-mitochondrial segments (NUMTs) are thought to be ancient, preceding human speciation. Here...
7.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams C, Walker S, et al.
Nature
. 2022 Mar;
607(7917):97-103.
PMID: 35255492
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of...
8.
Polubothu S, Zecchin D, Al-Olabi L, Lionarons D, Harland M, Horswell S, et al.
Genet Med
. 2021 Jun;
23(9):1636-1647.
PMID: 34145395
Purpose: Much of the heredity of melanoma remains unexplained. We sought predisposing germline copy-number variants using a rare disease approach. Methods: Whole-genome copy-number findings in patients with melanoma predisposition syndrome...
9.
Pagnamenta A, Kaiyrzhanov R, Zou Y, Daas S, Maroofian R, Donkervoort S, et al.
Brain
. 2021 Feb;
144(2):584-600.
PMID: 33559681
The extracellular matrix comprises a network of macromolecules such as collagens, proteoglycans and glycoproteins. VWA1 (von Willebrand factor A domain containing 1) encodes a component of the extracellular matrix that...
10.
Gabrysova L, Alvarez-Martinez M, Luisier R, Cox L, Sodenkamp J, Hosking C, et al.
Nat Immunol
. 2019 Feb;
20(3):374.
PMID: 30733606
In the version of this article initially published, the Supplementary Data file was an incorrect version. The correct version is now provided. The error has been corrected in the HTML...