Graham W Clarke
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Explore the profile of Graham W Clarke including associated specialties, affiliations and a list of published articles.
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12
Citations
167
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Recent Articles
1.
Khaleva E, Brightling C, Eiwegger T, Altraja A, Begin P, Blumchen K, et al.
Eur Respir J
. 2024 Nov;
PMID: 39510551
Background: We have previously developed Core Outcome Measures sets for Severe Asthma (COMSA) by multi-stakeholder consensus. There are no patient-centred tools to quantify response to biologics for severe asthma. We...
2.
Brinkman P, Wilde M, Ahmed W, Wang R, van der Schee M, Abuhelal S, et al.
Am J Respir Crit Care Med
. 2024 Jun;
210(9):1079-1090.
PMID: 38889337
The exhaled breath represents an ideal matrix for noninvasive biomarker discovery, and exhaled metabolomics have the potential to be clinically useful in the era of precision medicine. In this concise...
3.
Khaleva E, Rattu A, Brightling C, Bush A, Bossios A, Bourdin A, et al.
Eur Respir J
. 2022 Oct;
61(4).
PMID: 36229046
Background: Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core...
4.
Porsbjerg C, Maitland-van der Zee A, Brusselle G, Canonica G, Agusti A, Faner R, et al.
Eur Respir J
. 2021 Oct;
58(4).
PMID: 34675035
No abstract available.
5.
Patel N, Cunoosamy D, Fageras M, Taib Z, Asimus S, Hegelund-Myrback T, et al.
Int J Chron Obstruct Pulmon Dis
. 2018 Apr;
13:1009-1019.
PMID: 29628759
Background: p38 mitogen-activated protein kinase (MAPK) plays a central role in the regulation and activation of pro-inflammatory mediators. COPD patients have increased levels of activated p38 MAPK, which correlate with...
6.
Lexmond A, Singh D, Frijlink H, Clarke G, Page C, Forbes B, et al.
Pulm Pharmacol Ther
. 2018 Jan;
49:27-35.
PMID: 29331645
Inhaled airway challenges provoke bronchoconstriction in susceptible subjects and are a pivotal tool in the diagnosis and monitoring of obstructive lung diseases, both in the clinic and in the development...
7.
Singh D, Siew L, Christensen J, Plumb J, Clarke G, Greenaway S, et al.
Eur J Clin Pharmacol
. 2015 Aug;
71(10):1175-84.
PMID: 26265232
Background: Inhaled LPS causes neutrophilic airway inflammation in healthy subjects. We compared the effects of p38 MAPK inhibitors and fluticasone propionate on the LPS response. Methods: Three randomised, double-blind, placebo-controlled,...
8.
Diamant Z, Clarke G, Pieterse H, Gispert J
Curr Opin Pulm Med
. 2013 Nov;
20(1):37-45.
PMID: 24231465
Purpose Of Review: This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship...
9.
Clarke G, Diamant Z, Greenaway S, Rainer M, Allen E, Gispert J
Pulm Pharmacol Ther
. 2013 Jan;
26(3):400-1.
PMID: 23291284
No abstract available.
10.
Simcock D, Kanabar V, Clarke G, Mahn K, Karner C, OConnor B, et al.
Am J Respir Crit Care Med
. 2008 Jun;
178(5):460-8.
PMID: 18556625
Rationale: Airway remodeling in asthma involves accumulation of airway smooth muscle (ASM) and increased vascularity due to angiogenesis. Bronchial blood vessels and ASM are found in close proximity, and ASM...