Graham Rose
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Explore the profile of Graham Rose including associated specialties, affiliations and a list of published articles.
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21
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1449
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Recent Articles
11.
Gaulton T, Misra R, Rose G, Baybayan P, Hall R, Freeman J, et al.
Genome Announc
. 2015 Mar;
3(2).
PMID: 25814591
Clostridium difficile is one of the leading causes of antibiotic-associated diarrhea in health care facilities worldwide. Here, we report the genome sequence of C. difficile strain G46, ribotype 027, isolated...
12.
Houghton J, Cortes T, Schubert O, Rose G, Rodgers A, De Ste Croix M, et al.
PLoS One
. 2013 Dec;
8(12):e80047.
PMID: 24348997
Enhanced transcription of the Rv2660c locus in response to starvation of Mycobacterium tuberculosis H37Rv encouraged addition of the predicted Rv2660c protein to an improved vaccine formulation. Using strand-specific RNA sequencing,...
13.
Cortes T, Schubert O, Rose G, Arnvig K, Comas I, Aebersold R, et al.
Cell Rep
. 2013 Nov;
5(4):1121-31.
PMID: 24268774
Deciphering physiological changes that mediate transition of Mycobacterium tuberculosis between replicating and nonreplicating states is essential to understanding how the pathogen can persist in an individual host for decades. We...
14.
Rose G, Cortes T, Comas I, Coscolla M, Gagneux S, Young D
Genome Biol Evol
. 2013 Oct;
5(10):1849-62.
PMID: 24115728
Genome sequencing has identified an extensive repertoire of single nucleotide polymorphisms among clinical isolates of Mycobacterium tuberculosis, but the extent to which these differences influence phenotypic properties of the bacteria...
15.
Kato-Maeda M, Ho C, Passarelli B, Banaei N, Grinsdale J, Flores L, et al.
PLoS One
. 2013 Mar;
8(3):e58235.
PMID: 23472164
Rationale: Current tools available to study the molecular epidemiology of tuberculosis do not provide information about the directionality and sequence of transmission for tuberculosis cases occurring over a short period...
16.
Muller B, Borrell S, Rose G, Gagneux S
Trends Genet
. 2012 Dec;
29(3):160-9.
PMID: 23245857
Recent surveillance data of multidrug-resistant tuberculosis (MDR-TB) reported the highest rates of resistance ever documented. As further amplification of resistance in MDR strains of Mycobacterium tuberculosis occurs, extensively drug-resistant (XDR)...
17.
Comas I, Borrell S, Roetzer A, Rose G, Malla B, Kato-Maeda M, et al.
Nat Genet
. 2011 Dec;
44(1):106-10.
PMID: 22179134
Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently have reduced fitness compared to their drug-susceptible counterparts. Data from model systems suggest that the fitness cost of antimicrobial...
18.
Arnvig K, Comas I, Thomson N, Houghton J, Boshoff H, Croucher N, et al.
PLoS Pathog
. 2011 Nov;
7(11):e1002342.
PMID: 22072964
RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis by revealing an extensive presence of non-coding RNA, including long 5' and 3' untranslated regions, antisense transcripts, and...
19.
Omer H, Rose G, Jolley K, Frapy E, Zahar J, Maiden M, et al.
PLoS One
. 2011 Mar;
6(2):e17145.
PMID: 21386889
A scientist in our laboratory was accidentally infected while working with Z5463, a Neisseria meningitidis serogroup A strain. She developed severe symptoms (fever, meningism, purpuric lesions) that fortunately evolved with...
20.
He M, Sebaihia M, Lawley T, Stabler R, Dawson L, Martin M, et al.
Proc Natl Acad Sci U S A
. 2010 Apr;
107(16):7527-32.
PMID: 20368420
Clostridium difficile has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease, with the transcontinental spread of various PCR ribotypes, including 001, 017, 027 and 078. However, the genetic...