Graham P Pidgeon
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Explore the profile of Graham P Pidgeon including associated specialties, affiliations and a list of published articles.
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30
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904
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Recent Articles
1.
Barr M, Gray S, Gately K, Hams E, Fallon P, Mitchell Davies A, et al.
Mol Cancer
. 2020 Jan;
19(1):16.
PMID: 31987050
Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for...
2.
Mongan A, Lynam-Lennon N, Doyle S, Casey R, Carr E, Cannon A, et al.
Int J Med Sci
. 2019 Jun;
16(4):519-528.
PMID: 31171903
Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity status alter...
3.
McKenna M, McGarrigle S, Pidgeon G
Biochim Biophys Acta Rev Cancer
. 2018 Oct;
1870(2):185-197.
PMID: 30318472
The PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast cancer and key pathway aberrations have been identified which drive the different molecular subtypes. Early drugs developed targeting...
4.
Charmsaz S, Prencipe M, Kiely M, Pidgeon G, Collins D
Cancers (Basel)
. 2018 Jun;
10(6).
PMID: 29921753
Conventional therapies for cancer such as chemotherapy and radiotherapy remain a mainstay in treatment, but in many cases a targeted approach is lacking, and patients can be vulnerable to drug...
5.
Moore G, Pidgeon G
Int J Mol Sci
. 2017 Jan;
18(2).
PMID: 28125014
5-lipoxygenase is an enzyme responsible for the synthesis of a range of bioactive lipids signalling molecules known collectively as eicosanoids. 5-lipoxygenase metabolites such as 5-hydroxyeicosatetraenoic acid (5-HETE) and a number...
6.
Cathcart M, Useckaite Z, Drakeford C, Semik V, Lysaght J, Gately K, et al.
BMC Cancer
. 2016 Sep;
16:707.
PMID: 27586635
Background: Baicalein is a widely used Chinese herbal medicine derived from Scutellaria baicalenesis, which has been traditionally used as anti-inflammatory and anti-cancer therapy. In this study we examined the anti-tumour...
7.
Malley C, Pidgeon G
BBA Clin
. 2016 Apr;
5:29-40.
PMID: 27051587
The mechanistic target of rapamycin (mTOR) is a crucial point of convergence between growth factor signalling, metabolism, nutrient status and cellular proliferation. The mTOR pathway is heavily implicated in the...
8.
Barr M, Gray S, Gately K, Hams E, Fallon P, Mitchell Davies A, et al.
Mol Cancer
. 2015 Apr;
14:45.
PMID: 25889301
Background: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of...
9.
Lynam-Lennon N, Connaughton R, Carr E, Mongan A, OFarrell N, Porter R, et al.
BMC Cancer
. 2014 Dec;
14:907.
PMID: 25471892
Background: Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer,...
10.
Cathcart M, Gately K, Cummins R, Drakeford C, Kay E, OByrne K, et al.
Biochim Biophys Acta
. 2014 Feb;
1842(5):747-55.
PMID: 24480048
Background: Thromboxane synthase (TXS) metabolizes prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS over-expression has been reported in a range of cancers, and associated with angiogenesis...