Graeme J M Alexander
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Explore the profile of Graeme J M Alexander including associated specialties, affiliations and a list of published articles.
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52
Citations
1165
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Recent Articles
1.
Mela M, Smeeton W, Davies S, Miranda E, Scarpini C, Coleman N, et al.
Chronic Obstr Pulm Dis
. 2020 Jul;
7(3):151-162.
PMID: 32726073
Background: Alpha-1 antitrypsin deficiency (AATD) is an important, inherited cause of chronic liver disease. Marked variation in fibrosis stages in patients with homozygous deficiency and those factors that determine whether...
2.
Hirschfield G, Dyson J, Alexander G, Chapman M, Collier J, Hubscher S, et al.
Gut
. 2018 Mar;
67(9):1568-1594.
PMID: 29593060
Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis...
3.
Aravinthan A, Alexander G
J Hepatol
. 2016 Jun;
65(4):825-834.
PMID: 27245432
Cellular senescence is a fundamental, complex mechanism with an important protective role present from embryogenesis to late life across all species. It limits the proliferative potential of damaged cells thus...
4.
Chen A, Hoare M, Shankar A, Allison M, Alexander G, Michalak T
PLoS One
. 2015 Oct;
10(10):e0140312.
PMID: 26473969
Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited (spontaneous) resolution of hepatitis C was rarely investigated. The current...
5.
Tachtatzis P, Marshall A, Aravinthan A, Verma S, Penrhyn-Lowe S, Mela M, et al.
PLoS One
. 2015 Jul;
10(7):e0134315.
PMID: 26218071
No abstract available.
6.
Tachtatzis P, Marshall A, Arvinthan A, Aravinthan A, Verma S, Penrhyn-Lowe S, et al.
PLoS One
. 2015 May;
10(5):e0127511.
PMID: 26024529
Background: Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV might accelerate hepatocyte ageing and investigated the...
7.
Low G, Owen N, Joubert I, Patterson A, Graves M, Alexander G, et al.
Eur Radiol
. 2015 Apr;
25(10):2851-8.
PMID: 25903705
Objective: Hepatorenal syndrome (HRS) is the most lethal cause of renal impairment in cirrhosis. Magnetic resonance elastography (MRE) is a diagnostic test that characterises tissues based on their biomechanical properties....
8.
9.
Low G, Owen N, Joubert I, Patterson A, Graves M, Glaser K, et al.
J Magn Reson Imaging
. 2014 Dec;
42(3):844-50.
PMID: 25537823
Background: To evaluate the reliability of MRE using a spin-echo echo-planar imaging (SE-EPI) renal MRE technique in healthy volunteers. Methods: Institutional review board approved prospective study in which all participants...
10.
Tan L, Perez J, Mela M, Miranda E, Burling K, Rouhani F, et al.
Int J Biochem Cell Biol
. 2014 Dec;
58:81-91.
PMID: 25462157
α1-Antitrypsin is primarily synthesised in the liver, circulates to the lung and protects pulmonary tissues from proteolytic damage. The Z mutant (Glu342Lys) undergoes inactivating conformational change and polymerises. Polymers are...