Graeme Barker
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Explore the profile of Graeme Barker including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
313
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Recent Articles
1.
Wiejak J, Murphy F, Barker G, Maffia P, Yarwood S
Cell Signal
. 2024 Oct;
124:111444.
PMID: 39368792
This study explores the anti-inflammatory effects of non-cyclic nucleotide EPAC1 activators, PW0577 and SY007, on lipopolysaccharide (LPS)-induced responses in differentiated THP-1 macrophage-like cells. Both activators were found to selectively activate...
2.
Kubat J, Paterson R, Patramanis I, Barker G, Demeter F, Filoux A, et al.
PLoS One
. 2023 Dec;
18(12):e0291308.
PMID: 38100471
Pleistocene Pongo teeth show substantial variation in size and morphology, fueling taxonomic debates about the paleodiversity of the genus. We investigated prominent features of the enamel-dentine-junction junction (EDJ)-phylogenetically informative internal...
3.
Kusuma P, Cox M, Barker G, Sudoyo H, Lansing J, Jacobs G
Cell Rep
. 2023 Nov;
42(11):113346.
PMID: 37917587
Borneo was a crossroad of ancient dispersals, with some of the earliest Southeast Asian human remains and rock art. The island is home to traditionally hunter-gatherer Punan communities, whose origins,...
4.
Barker G, Rapposelli S
Molecules
. 2023 Aug;
28(15).
PMID: 37570616
The field of synthetic methodology plays a pivotal role in the quest for safe and effective drugs [...].
5.
Wiejak J, Luchowska-Stanska U, Wang P, Zhou J, Maffia P, Morgan D, et al.
Sci Rep
. 2022 Oct;
12(1):16505.
PMID: 36198739
The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial agonist of EPAC1. This was soon followed by the identification of the I942 analogues, PW0381, PW0521 and PWO577 and a...
6.
Wong J, Thomson C, Vilela F, Barker G
Chem Sci
. 2021 Nov;
12(40):13413-13424.
PMID: 34777760
Tetrazoles play a prominent role in medicinal chemistry due to their role as carboxylate bioisosteres but have largely been overlooked as C-H functionalisation substrates. We herein report the development of...
7.
Thomson C, Banks C, Allen M, Barker G, Coxon C, Lee A, et al.
J Org Chem
. 2021 Jul;
86(20):14079-14094.
PMID: 34270260
Recent advancements in in-line extraction and purification technology have enabled complex multistep synthesis in continuous flow reactor systems. However, for the large scope of chemical reactions that yield mixtures of...
8.
Pomeroy E, Hunt C, Reynolds T, Abdulmutalb D, Asouti E, Bennett P, et al.
Evol Anthropol
. 2020 Jul;
29(5):263-279.
PMID: 32652819
Mortuary behavior (activities concerning dead conspecifics) is one of many traits that were previously widely considered to have been uniquely human, but on which perspectives have changed markedly in recent...
9.
Wang P, Luchowska-Stanska U, van Basten B, Chen H, Liu Z, Wiejak J, et al.
J Med Chem
. 2020 Apr;
63(10):5159-5184.
PMID: 32340447
Exchange proteins directly activated by cAMP (EPAC) play a central role in various biological functions, and activation of the EPAC1 protein has shown potential benefits for the treatment of various...
10.
Beck E, Parnell E, Cowley A, Porter A, Gillespie J, Robinson J, et al.
Cells
. 2019 Nov;
8(11).
PMID: 31726720
Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell...