Grace K Pavlath
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Explore the profile of Grace K Pavlath including associated specialties, affiliations and a list of published articles.
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69
Citations
2848
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Recent Articles
1.
Banerjee A, Phillips B, Deng Q, Seyfried N, Pavlath G, Vest K, et al.
J Biol Chem
. 2019 Mar;
294(18):7360-7376.
PMID: 30837270
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset, primarily autosomal dominant disease caused by a short GCN expansion in the () gene that results in an alanine expansion at the N...
2.
Phillips B, Banerjee A, Sanchez B, Di Marco S, Gallouzi I, Pavlath G, et al.
Nucleic Acids Res
. 2018 Jun;
46(15):7643-7661.
PMID: 29939290
RNA processing is critical for proper spatial and temporal control of gene expression. The ubiquitous nuclear polyadenosine RNA binding protein, PABPN1, post-transcriptionally regulates multiple steps of gene expression. Mutations in...
3.
Cutler A, Corbett A, Pavlath G
Bio Protoc
. 2018 Mar;
7(24).
PMID: 29594187
Skeletal muscle provides the contractile force necessary for movement, swallowing, and breathing and, consequently, is necessary for survival. Skeletal muscle cells are unique in that they are extremely large cells...
4.
Cutler A, Jackson J, Corbett A, Pavlath G
J Cell Sci
. 2018 Jan;
131(3).
PMID: 29361530
Skeletal muscle is primarily composed of large myofibers containing thousands of post-mitotic nuclei distributed throughout a common cytoplasm. Protein production and localization in specialized myofiber regions is crucial for muscle...
5.
Banerjee A, Vest K, Pavlath G, Corbett A
Nucleic Acids Res
. 2017 Oct;
45(18):10706-10725.
PMID: 28977530
The polyadenylate binding protein 1 (PABPN1) is a ubiquitously expressed RNA binding protein vital for multiple steps in RNA metabolism. Although PABPN1 plays a critical role in the regulation of...
6.
Choo H, Canner J, Vest K, Thompson Z, Pavlath G
Am J Physiol Cell Physiol
. 2017 Jul;
313(4):C392-C404.
PMID: 28701357
Cell-cell adhesion molecules play key roles in maintaining quiescence or promoting activation of various stem cells in their niche. Muscle stem cells called satellite cells (SC) are critical for skeletal...
7.
Vest K, Phillips B, Banerjee A, Apponi L, Dammer E, Xu W, et al.
Hum Mol Genet
. 2017 Jun;
26(17):3235-3252.
PMID: 28575395
Oculopharyngeal muscular dystrophy (OPMD) is a late onset disease caused by polyalanine expansion in the poly(A) binding protein nuclear 1 (PABPN1). Several mouse models have been generated to study OPMD;...
8.
Cutler A, Dammer E, Doung D, Seyfried N, Corbett A, Pavlath G
Aging Cell
. 2017 May;
16(4):738-749.
PMID: 28544616
Skeletal muscle aging is accompanied by loss of muscle mass and strength. Examining changes in myonuclear proteins with age would provide insight into molecular processes which regulate these profound changes...
9.
Vest K, Apponi L, Banerjee A, Pavlath G, Corbett A
J Neuromuscul Dis
. 2016 Nov;
2(4):439-446.
PMID: 27858752
Background: Oculopharyngeal muscular dystrophy (OPMD), a late onset disorder affecting specific skeletal muscles, is caused by a (GCG)n expansion mutation in the gene encoding the mRNA processing protein, polyadenylate binding...
10.
Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import
Choo H, Cutler A, Rother F, Bader M, Pavlath G
Stem Cells
. 2016 Jul;
34(11):2784-2797.
PMID: 27434733
Satellite cells are stem cells with an essential role in skeletal muscle repair. Precise regulation of gene expression is critical for proper satellite cell quiescence, proliferation, differentiation and self-renewal. Nuclear...