Graca Soveral
Overview
Explore the profile of Graca Soveral including associated specialties, affiliations and a list of published articles.
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93
Citations
1584
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Recent Articles
1.
Pimpao C, da Silva I, Soveral G
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39941100
Aquaporins (AQPs) are transmembrane proteins that facilitate the transport of water and small solutes, including glycerol, hydrogen peroxide and ions, across cell membranes. Beyond their established physiological roles in water...
2.
Pinho J, Coelho M, Pimpao C, Konwar J, Godinho-Santos A, Noiva R, et al.
Pharmaceutics
. 2025 Jan;
16(12.
PMID: 39771545
The therapeutic management of melanoma, the most aggressive form of skin cancer, remains challenging. In the search for more effective therapeutic options, metal-based complexes are being investigated for their anticancer...
3.
da Silva I, Mlinaric M, Lourenco A, Perez-Garcia O, cipak Gasparovic A, Soveral G
Int J Mol Sci
. 2024 Aug;
25(15).
PMID: 39125952
Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins primarily known for facilitating water transport across cell membranes. In addition to the classical water transport function, peroxiporins...
4.
da Silva I, Pimpao C, Paccetti-Alves I, Thomas S, Barateiro A, Casini A, et al.
J Physiol
. 2024 Feb;
602(13):3111-3129.
PMID: 38323926
Aquaporin-3 (AQP3) is a membrane channel with dual aquaglyceroporin/peroxiporin activity, facilitating the diffusion of water, glycerol and HO across cell membranes. AQP3 shows aberrant expression in melanoma and its role...
5.
Lopes P, Fonseca E, da Silva I, Vigia E, Paulino J, Soveral G
Genes (Basel)
. 2023 Sep;
14(9).
PMID: 37761834
Pancreatic cancer is anticipated to be the second leading cause of cancer-related death by 2030. Aquaporins (AQPs), a family of water channel proteins, have been linked to carcinogenesis. The aim...
6.
da Silva I, Coelho D, Mestre Prates J, Soveral G, Lopes P
Front Biosci (Landmark Ed)
. 2023 Jul;
28(6):126.
PMID: 37395039
Background: Lipopolysaccharide (LPS), an effective stimulator of the immune system, has been widely applied in an experimental pig model for human sepsis. Aquaporins (AQPs), a family of small integral membrane...
7.
Mlinaric M, Lucic I, Milkovic L, da Silva I, Tartaro Bujak I, Musani V, et al.
Int J Mol Sci
. 2023 May;
24(9).
PMID: 37175840
Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression and malignancy and is,...
8.
Paccetti-Alves I, Batista M, Pimpao C, Victor B, Soveral G
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36983077
The natural polyphenolic compound Rottlerin (RoT) showed anticancer properties in a variety of human cancers through the inhibition of several target molecules implicated in tumorigenesis, revealing its potential as an...
9.
Fruhbeck G, Mendez-Gimenez L, Becerril S, Ramirez B, Hernandez-Pardos A, Cienfuegos J, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834823
Glycerol is a key metabolite for lipid accumulation in insulin-sensitive tissues. We examined the role of aquaporin-7 (AQP7), the main glycerol channel in adipocytes, in the improvement of brown adipose...
10.
da Silva I, Soveral G
Adv Exp Med Biol
. 2023 Jan;
1398:289-302.
PMID: 36717502
Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance...