Gowrishankar Muthukrishnan
Overview
Explore the profile of Gowrishankar Muthukrishnan including associated specialties, affiliations and a list of published articles.
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37
Citations
767
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Recent Articles
1.
Saito M, McDonald K, Grier A, Grier A, Meghwani H, Rangel-Moreno J, et al.
bioRxiv
. 2025 Jan;
PMID: 39803468
prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don't exist. Multi-omics studies in a humanized NSG-SGM3 BLT mouse model demonstrate...
2.
Kates S, Owen J, Xie C, Ren Y, Muthukrishnan G, Schwarz E
Injury
. 2024 Oct;
55 Suppl 6:111631.
PMID: 39482036
Although vaccines have been hailed as one of the greatest advances in medicine based on their unparalleled cost-effectiveness in eradicating life-threatening infectious diseases, their role in orthopedic trauma-related infections is...
3.
McDonald K, Rodriguez A, Muthukrishnan G
Antibiotics (Basel)
. 2024 Jul;
13(7).
PMID: 39061322
Bacterial infections continue to represent a significant healthcare burden worldwide, causing considerable mortality and morbidity every year. The emergence of multidrug-resistant bacterial strains continues to rise, posing serious risks to...
4.
Kates S, Owen J, Beck C, Muthukrishnan G, Daiss J, Golladay G
J Orthop Res
. 2024 Jul;
42(12):2835-2843.
PMID: 39054760
The incidence of prosthetic joint infection (PJI) following elective primary total knee arthroplasty (TKA) is very low but serious risk remains. To identify unknown risk factors, we completed a natural...
5.
Botros M, Bentley K, Schloemann D, Saito M, Constantine R, Ricciardi B, et al.
J Orthop Res
. 2024 Jul;
42(11):2593-2603.
PMID: 39044717
Cutibacterium acnes, part of normal skin flora, is increasingly recognized as an opportunistic pathogen capable of causing chronic prosthetic joint infections (PJI) associated with total hip and knee arthroplasty. However,...
6.
Hofstee M, Siverino C, Saito M, Meghwani H, Tapia-Dean J, Arveladze S, et al.
JBMR Plus
. 2024 Mar;
8(2):ziad005.
PMID: 38505530
is the most common pathogen that causes implant-associated osteomyelitis, a clinically incurable disease. Immune evasion of relies on various mechanisms to survive within the bone niche, including the secretion of...
7.
Schwarz E, Archer N, Atkins G, Bentley K, Botros M, Cassat J, et al.
J Orthop Res
. 2023 Dec;
42(3):518-530.
PMID: 38102985
Musculoskeletal infections (MSKI), which are a major problem in orthopedics, occur when the pathogen eludes or overwhelms the host immune system. While effective vaccines and immunotherapies to prevent and treat...
8.
Xie C, Ren Y, Weeks J, Rainbolt J, Kenney H, Xue T, et al.
J Orthop Res
. 2023 Oct;
42(3):531-538.
PMID: 37812184
Critical knowledge gaps of orthopedic infections pertain to bacterial colonization. The established dogma termed the Race for the Surface posits that contaminating bacteria compete with host cells for the implant...
9.
Kenney H, Rangel-Moreno J, Peng Y, Chen K, Bruno J, Embong A, et al.
Front Immunol
. 2023 Sep;
14:1237498.
PMID: 37691918
Introduction: Defective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying...
10.
Hachem A, Filkins L, Kidane Y, Raj P, Tareen N, Arana C, et al.
PLoS One
. 2023 Aug;
18(8):e0288758.
PMID: 37561761
There is substantial genomic heterogeneity among Staphylococcus aureus isolates of children with acute hematogenous osteomyelitis (AHO) but transcriptional behavior of clinically differentiated strains has not been previously described. This study...