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Gow-Chin Yen

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Articles 188
Citations 4028
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Recent Articles
1.
Liao C, Chen S, Chen Y, Huang C, Pan R, Yen G
Int J Biol Macromol . 2025 Jan; 295:139577. PMID: 39778852
The rising pandemic of obesity has received significant attention. Yet, more safe and effective targeted strategies must be used to mitigate its impact on individual health and the global disease...
2.
Tang Y, Chuang Y, Chang H, Juang S, Yen G, Chang J, et al.
J Food Drug Anal . 2024 Dec; 31(3):387-407. PMID: 39666284
Induction of antioxidant proteins and phase 2 detoxifying enzymes that neutralize reactive electrophiles are important mechanisms for protection against carcinogenesis. Normal cells provide multifaceted pathways to tightly control NF-E2-related factor...
3.
Huang Y, Chen S, Li T, Tsai Y, Chen C, Yen G
Food Funct . 2024 Oct; 15(23):11491-11507. PMID: 39480654
Excessive alcohol consumption is a significant pathogenic factor involved in the initiation of noninfectious gastric ulcers. Probiotics based on a specific strain can mitigate gastric damage. However, the protective effects...
4.
Chen S, Chiang I, Chen Y, Hsu Y, Yen G
Food Res Int . 2024 Sep; 194:114907. PMID: 39232532
Methylglyoxal (MG) serves as the primary precursor for the nonenzymatic glycation of proteins and DNA, leading to advanced glycation end products (AGEs). Regular intake of dietary MG is strongly correlated...
5.
Liu Y, Chen S, Chen Y, Chang H, Chiang I, Yen G
Int J Biol Macromol . 2024 Jul; 276(Pt 2):133898. PMID: 39019369
Patients may find it challenging to accept several FDA-approved drugs for Alzheimer's disease (AD) treatment due to their unaffordable prices and side effects. Despite the known antioxidant, anti-inflammatory, and microbiota-regulating...
6.
Chang H, Chen S, Lin J, Chen Y, Chen Y, Liu Y, et al.
J Agric Food Chem . 2024 Apr; 72(18):10406-10419. PMID: 38659208
The impact of leptin resistance on intestinal mucosal barrier integrity, appetite regulation, and hepatic lipid metabolism through the microbiota-gut-brain-liver axis has yet to be determined. Water extract of L. fruit...
7.
Chen S, Huang Y, Lin J, Yen G
J Food Drug Anal . 2024 Mar; 32(1):54-64. PMID: 38526590
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In...
8.
Chiang I, Chen S, Hsu Y, Shahidi F, Yen G
Eur J Pharmacol . 2024 Feb; 967:176393. PMID: 38325792
Sunitinib (SUN) is the first-line targeted therapeutic drug for advanced renal cell carcinoma (RCC). However, SUN resistance is frequently observed to result in tumor metastasis, with a poor survival rate....
9.
Chen Y, Chen S, Chang H, Liu Y, Chuang B, Yen G
Int J Biol Macromol . 2023 Dec; 258(Pt 2):129043. PMID: 38158054
Pharmacological treatments for colitis have limited efficacy and side effects. Plant polysaccharides improve colitis by modulating the gut microbiota. However, the specific benefits of Phyllanthus emblica L. polysaccharides (PEPs) in...
10.
Chen Y, Chen S, Lin J, Yen G
Mol Nutr Food Res . 2023 Feb; 67(7):e2200791. PMID: 36738163
Scope: Methylglyoxal (MG)-derived advanced glycation end products (AGEs) directly bind to the receptor for advanced glycation end products (RAGE), subsequently exacerbating obesity and obesity-induced cognitive decline. Indian gooseberry (Phyllanthus emblica...