Govind V Kaigala
Overview
Explore the profile of Govind V Kaigala including associated specialties, affiliations and a list of published articles.
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Articles
48
Citations
351
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Recent Articles
1.
Pereiro I, Fomitcheva-Khartchenko A, Kaigala G
Methods Mol Biol
. 2024 May;
2804:103-115.
PMID: 38753143
In this chapter, we present the design and fabrication of a device and implementation of a protocol to realize increased efficiency of immunoassays within microtiter plates. The device, WellProbe, is...
2.
Paratore F, Bacheva V, Bercovici M, Kaigala G
Nat Rev Chem
. 2023 Apr;
6(1):70-80.
PMID: 37117618
Lab-on-a-chip devices leverage microfluidic technologies to enable chemical and biological processes at small scales. However, existing microfluidic channel networks are typically designed for the implementation of a single function or...
3.
Fomitcheva-Khartchenko A, Kashyap A, Geiger T, Kaigala G
Trends Cancer
. 2022 Aug;
8(12):1019-1032.
PMID: 35995681
Tumor cells present complex behaviors in their interactions with other cells. This intricate behavior is driving the need to develop new tools to understand these ecosystems. The surge of spatial...
4.
Mathur P, Khartchenko A, Stavrakis S, Kaigala G, deMello A
Anal Chem
. 2022 Jul;
94(31):10967-10975.
PMID: 35895913
We present a method for monitoring spatially localized antigen-antibody binding events on physiologically relevant substrates (cell and tissue sections) using fluorescence lifetime imaging. Specifically, we use the difference between the...
5.
Bacheva V, Paratore F, Bar-Dolev M, Rofman B, Kaigala G, Bercovici M
Anal Chem
. 2022 Jul;
94(30):10584-10588.
PMID: 35861417
We present a microfluidic device for selective separation and extraction of molecules based on their diffusivity. The separation relies on electroosmotically driven bidirectional flows in which high-diffusivity species experience a...
6.
Taylor D, Mathur P, Renaud P, Kaigala G
Lab Chip
. 2022 Mar;
22(8):1415-1437.
PMID: 35348555
Hydrodynamic phenomena can be leveraged to confine a range of biological and chemical species without needing physical walls. In this review, we list methods for the generation and manipulation of...
7.
Pereiro I, Kartchenko A, Lovchik R, Kaigala G
Analyst
. 2022 Mar;
147(10):2040-2047.
PMID: 35297447
We propose microfluidic add-ons that can be easily added onto standard assay labware such as microwells and slides to enhance the kinetics of immunoassays. We design these monolithic devices having...
8.
Fomitcheva-Khartchenko A, Rapsomaniki M, Sobottka B, Schraml P, Kaigala G
PLoS One
. 2021 Nov;
16(11):e0259332.
PMID: 34797831
A new workflow for protein-based tumor heterogeneity probing in tissues is here presented. Tumor heterogeneity is believed to be key for therapy failure and differences in prognosis in cancer patients....
9.
Delamarche E, Pereiro I, Kashyap A, Kaigala G
Langmuir
. 2021 Aug;
37(32):9637-9651.
PMID: 34347483
Patterning biomolecules on surfaces provides numerous opportunities for miniaturizing biological assays; biosensing; studying proteins, cells, and tissue sections; and engineering surfaces that include biological components. In this Feature Article, we...
10.
Pereiro I, Khartchenko A, Lovchik R, Kaigala G
Angew Chem Int Ed Engl
. 2021 Jul;
60(38):20935-20942.
PMID: 34296491
Surface assays such as ELISA are pervasive in clinics and research and predominantly standardized in microtiter plates (MTP). MTPs provide many advantages but are often detrimental to surface assay efficiency...