Goutham B Manjunath
Overview
Explore the profile of Goutham B Manjunath including associated specialties, affiliations and a list of published articles.
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15
Citations
281
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Recent Articles
1.
Yarlagadda V, Manjunath G, Sarkar P, Akkapeddi P, Paramanandham K, Shome B, et al.
ACS Infect Dis
. 2016 Sep;
2(2):132-9.
PMID: 27624964
The emergence of drug resistance along with a declining pipeline of clinically useful antibiotics has made it vital to develop more effective antimicrobial therapeutics, particularly against difficult-to-treat Gram-negative pathogens (GNPs)....
2.
Ghosh C, Manjunath G, Konai M, Uppu D, Paramanandham K, Shome B, et al.
ACS Infect Dis
. 2016 Sep;
2(2):111-22.
PMID: 27624962
Infections caused by drug-resistant Gram-negative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi metallo-β-lactamase-1 (blaNDM-1) producing pathogens, against which few drugs remain active,...
3.
Hoque J, Konai M, Samaddar S, Gonuguntala S, Manjunath G, Ghosh C, et al.
Chem Commun (Camb)
. 2016 Aug;
52(69):10582.
PMID: 27502077
Correction for 'Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms' by Jiaul Hoque et al., Chem. Commun., 2015, 51, 13670-13673.
4.
Ghosh C, Manjunath G, Konai M, Uppu D, Hoque J, Paramanandham K, et al.
PLoS One
. 2015 Dec;
10(12):e0144094.
PMID: 26669634
Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of aryl-alkyl-lysines, simple...
5.
Yarlagadda V, Sarkar P, Manjunath G, Haldar J
Bioorg Med Chem Lett
. 2015 Nov;
25(23):5477-80.
PMID: 26525861
Antibiotic-resistant superbugs such as vancomycin-resistant Enterococci (VRE) and Staphylococci have become a major global health hazard. To address this issue, we synthesized vancomycin aglycon dimers to systematically probe the impact...
6.
Hoque J, Konai M, Samaddar S, Gonuguntala S, Manjunath G, Ghosh C, et al.
Chem Commun (Camb)
. 2015 Jul;
51(71):13670-3.
PMID: 26226319
Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this...
7.
Hoque J, Konai M, Gonuguntla S, Manjunath G, Samaddar S, Yarlagadda V, et al.
J Med Chem
. 2015 Jun;
58(14):5486-500.
PMID: 26102297
Treating bacterial biofilms with conventional antibiotics is limited due to ineffectiveness of the drugs and higher propensity to develop bacterial resistance. Development of new classes of antibacterial therapeutics with alternative...
8.
Yarlagadda V, Konai M, Manjunath G, Prakash R, Mani B, Paramanandham K, et al.
Int J Antimicrob Agents
. 2015 Apr;
45(6):627-34.
PMID: 25900818
The membrane-active glycopeptide antibiotic YV11455 is a lipophilic cationic vancomycin analogue that demonstrates rapid and concentration-dependent killing of clinically relevant multidrug-resistant (MDR) Gram-positive bacteria in vitro. YV11455 was 2-fold and...
9.
Uppu D, Manjunath G, Yarlagadda V, Kaviyil J, Ravikumar R, Paramanandham K, et al.
PLoS One
. 2015 Apr;
10(4):e0126757.
PMID: 25879927
Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old antibiotics' and halt the...
10.
Uppu D, Manjunath G, Yarlagadda V, Kaviyil J, Ravikumar R, Paramanandham K, et al.
PLoS One
. 2015 Mar;
10(3):e0119422.
PMID: 25789871
Gram-negative 'superbugs' such as New Delhi metallo-beta-lactamase-1 (blaNDM-1) producing pathogens have become world's major public health threats. Development of molecular strategies that can rehabilitate the 'old antibiotics' and halt the...