Gladys A Ngoh
Overview
Explore the profile of Gladys A Ngoh including associated specialties, affiliations and a list of published articles.
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15
Citations
1419
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Recent Articles
1.
Papanicolaou K, Kikuchi R, Ngoh G, Coughlan K, Dominguez I, Stanley W, et al.
Circ Res
. 2012 Aug;
111(8):1012-26.
PMID: 22904094
Rationale: At birth, there is a switch from placental to pulmonary circulation and the heart commences its aerobic metabolism. In cardiac myocytes, this transition is marked by increased mitochondrial biogenesis...
2.
Ngoh G, Papanicolaou K, Walsh K
J Biol Chem
. 2012 Apr;
287(24):20321-32.
PMID: 22511781
The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its role in ER stress is...
3.
Facundo H, Brainard R, Watson L, Ngoh G, Hamid T, Prabhu S, et al.
Am J Physiol Heart Circ Physiol
. 2012 Mar;
302(10):H2122-30.
PMID: 22408028
The regulation of cardiomyocyte hypertrophy is a complex interplay among many known and unknown processes. One specific pathway involves the phosphatase calcineurin, which regulates nuclear translocation of the essential cardiac...
4.
Papanicolaou K, Ngoh G, Dabkowski E, OConnell K, Ribeiro Jr R, Stanley W, et al.
Am J Physiol Heart Circ Physiol
. 2011 Nov;
302(1):H167-79.
PMID: 22037195
Molecular studies examining the impact of mitochondrial morphology on the mammalian heart have previously focused on dynamin related protein-1 (Drp-1) and mitofusin-2 (Mfn-2), while the role of the other mitofusin...
5.
Lugus J, Ngoh G, Bachschmid M, Walsh K
J Mol Cell Cardiol
. 2011 Aug;
51(6):885-93.
PMID: 21839087
The mitofusin proteins MFN1 and MFN2 function to maintain mitochondrial networks by binding one another and initiating outer mitochondrial membrane fusion. While it has recently been recognized that vascular endothelial...
6.
Papanicolaou K, Khairallah R, Ngoh G, Chikando A, Luptak I, OShea K, et al.
Mol Cell Biol
. 2011 Jan;
31(6):1309-28.
PMID: 21245373
Mitofusin-2 (Mfn-2) is a dynamin-like protein that is involved in the rearrangement of the outer mitochondrial membrane. Research using various experimental systems has shown that Mfn-2 is a mediator of...
7.
Watson L, Facundo H, Ngoh G, Ameen M, Brainard R, Lemma K, et al.
Proc Natl Acad Sci U S A
. 2010 Sep;
107(41):17797-802.
PMID: 20876116
The failing heart is subject to elevated metabolic demands, adverse remodeling, chronic apoptosis, and ventricular dysfunction. The interplay among such pathologic changes is largely unknown. Several laboratories have identified a...
8.
Ngoh G, Watson L, Facundo H, Jones S
Amino Acids
. 2010 Aug;
40(3):895-911.
PMID: 20798965
O-linked β-N-acetylglucosamine (O-GlcNAc) is an inducible, dynamically cycling and reversible post-translational modification of Ser/Thr residues of nucleocytoplasmic and mitochondrial proteins. We recently discovered that O-GlcNAcylation confers cytoprotection in the heart...
9.
Ngoh G, Facundo H, Zafir A, Jones S
Circ Res
. 2010 Jul;
107(2):171-85.
PMID: 20651294
Cardiovascular function is regulated at multiple levels. Some of the most important aspects of such regulation involve alterations in an ever-growing list of posttranslational modifications. One such modification orchestrates input...
10.
Schaller S, Paradis S, Ngoh G, Assaly R, Buisson B, Drouot C, et al.
J Pharmacol Exp Ther
. 2010 Mar;
333(3):696-706.
PMID: 20215409
3,5-Seco-4-nor-cholestan-5-one oxime-3-ol (TRO40303) is a new cardioprotective compound coming from a chemical series identified initially for neuroprotective properties. TRO40303 binds specifically to the mitochondrial translocator protein 18 kDa (TSPO) at...