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Giusy Laudati

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Articles 21
Citations 265
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Recent Articles
1.
Valsecchi V, Errico F, Bassareo V, Marino C, Nuzzo T, Brancaccio P, et al.
Commun Biol . 2023 Nov; 6(1):1155. PMID: 37957344
Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical...
2.
Valsecchi V, Laudati G, Cuomo O, Sirabella R, Del Prete A, Annunziato L, et al.
Cell Death Dis . 2023 Jul; 14(7):484. PMID: 37524689
No abstract available.
3.
Casamassa A, Cuomo O, Pannaccione A, Cepparulo P, Laudati G, Valsecchi V, et al.
Cell Calcium . 2022 Jun; 105:102608. PMID: 35667322
The intricate glia interaction occurring after stroke strongly depend on the maintenance of intraglial ionic homeostasis. Among the several ionic channels and transporters, the plasmamembrane Na/Ca exchanger (NCX) represents a...
4.
Anzilotti S, Valsecchi V, Brancaccio P, Guida N, Laudati G, Tedeschi V, et al.
Neurobiol Dis . 2021 Aug; 159:105480. PMID: 34411705
Imbalance in cellular ionic homeostasis is a hallmark of several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS). Sodium-calcium exchanger (NCX) is a membrane antiporter that, operating in a bidirectional way,...
5.
Valsecchi V, Laudati G, Cuomo O, Sirabella R, Del Prete A, Annunziato L, et al.
Cell Death Dis . 2021 May; 12(5):423. PMID: 33931586
Remote limb ischemic postconditioning (RLIP) is an experimental strategy in which short femoral artery ischemia reduces brain damage induced by a previous harmful ischemic insult. Ionic homeostasis maintenance in the...
6.
Cuomo O, Casamassa A, Brancaccio P, Laudati G, Valsecchi V, Anzilotti S, et al.
Cell Calcium . 2020 Apr; 87:102195. PMID: 32240869
The small ubiquitin-like modifier (SUMO) conjugation (or SUMOylation) is a post-translational protein modification mechanism activated by different stress conditions that has been recently investigated in experimental models of cerebral ischemia....
7.
Formisano L, Guida N, Mascolo L, Serani A, Laudati G, Pizzorusso V, et al.
Cell Calcium . 2020 Mar; 87:102194. PMID: 32172011
Sodium-calcium exchanger (NCX) 1 and 3, have been demonstrated to play a relevant role in controlling the intracellular homeostasis of sodium and calcium ions in physiological and patho-physiological conditions. While...
8.
Valsecchi V, Anzilotti S, Serani A, Laudati G, Brancaccio P, Guida N, et al.
Mol Ther . 2020 Feb; 28(4):1154-1166. PMID: 32075715
Spinal muscular atrophy (SMA) is a severe neuromuscular disease affecting infants caused by alterations of the survival motor neuron gene, which results in progressive degeneration of motor neurons (MNs). Although...
9.
Formisano L, Laudati G, Guida N, Mascolo L, Serani A, Cuomo O, et al.
J Cereb Blood Flow Metab . 2019 Nov; 40(10):2081-2097. PMID: 31696766
The histone deacetylases (HDACs)-dependent mechanisms regulating gene transcription of the Na/Ca exchanger isoform 3 () after stroke are still unknown. Overexpression or knocking-down of HDAC4/HDAC5 down-regulates or increases, respectively, NCX3...
10.
Lauritano A, Moutton S, Longobardi E, Mau-Them F, Laudati G, Nappi P, et al.
Epilepsia Open . 2019 Aug; 4(3):464-475. PMID: 31440727
Objective: Heterozygous variants in or, more rarely, genes are responsible for early-onset developmental/epileptic disorders characterized by heterogeneous clinical presentation and course, genetic transmission, and prognosis. While familial forms mostly include...