Giuseppina Maccarrone
Overview
Explore the profile of Giuseppina Maccarrone including associated specialties, affiliations and a list of published articles.
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52
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1107
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Recent Articles
1.
Di Matteo F, Bonrath R, Pravata V, Schmidt H, Ayo Martin A, Di Giaimo R, et al.
Nat Commun
. 2025 Feb;
16(1):1737.
PMID: 39966398
Periventricular heterotopia (PH), a common form of gray matter heterotopia associated with developmental delay and drug-resistant seizures, poses a challenge in understanding its neurophysiological basis. Human cerebral organoids (hCOs) derived...
2.
Forero A, Pipicelli F, Moser S, Baumann N, Gratz C, Gonzalez Pisfil M, et al.
Cell Rep
. 2024 Sep;
43(10):114755.
PMID: 39302835
Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of...
3.
Pipicelli F, Baumann N, Di Giaimo R, Forero-Echeverry A, Kyrousi C, Bonrath R, et al.
Sci Adv
. 2023 May;
9(20):eadd8164.
PMID: 37205765
Disruption in neurogenesis and neuronal migration can influence the assembly of cortical circuits, affecting the excitatory-inhibitory balance and resulting in neurodevelopmental and neuropsychiatric disorders. Using ventral cerebral organoids and dorsoventral...
4.
Contini C, Serrao S, Manconi B, Olianas A, Iavarone F, Guadalupi G, et al.
Life (Basel)
. 2023 Mar;
13(3).
PMID: 36983903
Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer's...
5.
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Martinelli S, Anderzhanova E, Bajaj T, Wiechmann S, Dethloff F, Weckmann K, et al.
Nat Commun
. 2021 Jul;
12(1):4643.
PMID: 34330919
The stress response is an essential mechanism for maintaining homeostasis, and its disruption is implicated in several psychiatric disorders. On the cellular level, stress activates, among other mechanisms, autophagy that...
6.
Misiewicz Z, Iurato S, Kulesskaya N, Salminen L, Rodrigues L, Maccarrone G, et al.
PLoS Genet
. 2019 Sep;
15(9):e1008358.
PMID: 31557158
Stressful life events are major environmental risk factors for anxiety disorders, although not all individuals exposed to stress develop clinical anxiety. The molecular mechanisms underlying the influence of environmental effects...
7.
Weckmann K, Deery M, Howard J, Feret R, Asara J, Dethloff F, et al.
Mol Neuropsychiatry
. 2019 Apr;
5(1):42-51.
PMID: 31019917
Ketamine, a noncompetitive, voltage-dependent N-Methyl-D-aspartate receptor (NMDAR) antagonist, has been shown to have a rapid antidepressant effect and is used for patients experiencing treatment-resistant depression. We carried out a time-dependent...
8.
Ising M, Maccarrone G, Bruckl T, Scheuer S, Hennings J, Holsboer F, et al.
Int J Mol Sci
. 2019 Jan;
20(3).
PMID: 30678080
Adverse experiences and chronic stress are well-known risk factors for the development of major depression, and an impaired stress response regulation is frequently observed in acute depression. Impaired glucocorticoid receptor...
9.
Weckmann K, Deery M, Howard J, Feret R, Asara J, Dethloff F, et al.
Sci Rep
. 2017 Nov;
7(1):15788.
PMID: 29150633
Fewer than 50% of all patients with major depressive disorder (MDD) treated with currently available antidepressants (ADs) show full remission. Moreover, about one third of the patients suffering from MDD...
10.
Turck C, Guest P, Maccarrone G, Ising M, Kloiber S, Lucae S, et al.
Front Mol Neurosci
. 2017 Sep;
10:272.
PMID: 28912679
The current inability of clinical psychiatry to objectively select the most appropriate treatment is a major factor contributing to the severity and clinical burden of major depressive disorder (MDD). Here,...