Giuliana Fusco
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Explore the profile of Giuliana Fusco including associated specialties, affiliations and a list of published articles.
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38
Citations
1324
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Recent Articles
1.
Esposito A, Leone L, De Simone A, Fusco G, Nastri F, Lombardi A
ACS Appl Mater Interfaces
. 2024 Aug;
16(34):45371-45382.
PMID: 39140178
The self-assembly of proteins and peptides into fibrillar amyloid aggregates is a highly promising route to define the next generation of functional nanomaterials. Amyloid fibrils, traditionally associated with neurodegenerative diseases,...
2.
Immune responses to oligomeric α-synuclein in Parkinson's disease peripheral blood mononuclear cells
Vega-Benedetti A, Porcedda C, Ercoli T, Fusco G, Burgaletto C, Pillai R, et al.
J Neurol
. 2024 Jul;
271(9):5916-5929.
PMID: 38985290
Parkinson's disease displays clinical heterogeneity, presenting with motor and non-motor symptoms. Heterogeneous phenotypes, named brain-first and body-first, may reflect distinct α-synuclein pathology starting either in the central nervous system or...
3.
Gallo A, Mansueto S, Emendato A, Fusco G, De Simone A
JACS Au
. 2024 Jun;
4(6):2372-2380.
PMID: 38938811
The characterization of intrinsically disordered regions (IDRs) in membrane-associated proteins is of crucial importance to elucidate key biochemical processes, including cellular signaling, drug targeting, or the role of post-translational modifications....
4.
Chen S, Barritt J, Cascella R, Bigi A, Cecchi C, Banchelli M, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10537-10549.
PMID: 38567991
The aberrant aggregation of α-synuclein (αS) into amyloid fibrils is associated with a range of highly debilitating neurodegenerative conditions, including Parkinson's disease. Although the structural properties of mature amyloids of...
5.
Manchinu M, Pala M, Palmas M, Diana M, Maschio A, Etzi M, et al.
Exp Neurol
. 2023 Dec;
372:114651.
PMID: 38092188
Mild cognitive impairment (MCI) is a common trait of Parkinson's disease (PD), often associated with early motor deficits, eventually evolving to PD with dementia in later disease stages. The neuropathological...
6.
Mansueto S, Fusco G, De Simone A
Chem Commun (Camb)
. 2023 Jun;
59(57):8769-8778.
PMID: 37345454
The aberrant aggregation of α-Synuclein (αS), a disordered protein primarily localised at the neuronal synapses, is associated with a number of neurodegenerative disorders including Parkinson's disease (PD). The biological properties...
7.
Gonzalez-Garcia M, Fusco G, De Simone A
Front Chem
. 2023 May;
11:1167766.
PMID: 37201129
The aberrant aggregation of α-synuclein (αS), a disordered protein primarily expressed in neuronal cells, is strongly associated with the underlying mechanisms of Parkinson's disease. It is now established that αS...
8.
Reimer L, Gram H, Jensen N, Betzer C, Yang L, Jin L, et al.
PNAS Nexus
. 2023 Jan;
1(5):pgac259.
PMID: 36712380
Aggregated α-synuclein (α-syn) accumulates in the neuronal Lewy body (LB) inclusions in Parkinson's disease (PD) and LB dementia. Yet, under nonpathological conditions, monomeric α-syn is hypothesized to exist in an...
9.
Fusco G, Biancaniello C, Vrettas M, De Simone A
Front Mol Biosci
. 2022 Dec;
9:1037445.
PMID: 36518847
Water at the protein surface is an active biological molecule that plays a critical role in many functional processes. Using NMR-restrained MD simulations, we here addressed how protein hydration is...
10.
Fusco G, Bemporad F, Chiti F, Dobson C, De Simone A
Front Mol Biosci
. 2022 Sep;
9:981312.
PMID: 36158582
Proteins from hyperthermophilic organisms are evolutionary optimised to adopt functional structures and dynamics under conditions in which their mesophilic homologues are generally inactive or unfolded. Understanding the nature of such...