Giselle P Lim
Overview
Explore the profile of Giselle P Lim including associated specialties, affiliations and a list of published articles.
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14
Citations
2122
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Recent Articles
1.
Begum A, Jones M, Lim G, Morihara T, Kim P, Heath D, et al.
J Pharmacol Exp Ther
. 2008 Apr;
326(1):196-208.
PMID: 18417733
Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and metabolism raise concerns, including whether the more stable metabolite tetrahydrocurcumin (TC) may mediate efficacy. We examined the antioxidant, anti-inflammatory,...
2.
Kotilinek L, Westerman M, Wang Q, Panizzon K, Lim G, Simonyi A, et al.
Brain
. 2008 Feb;
131(Pt 3):651-64.
PMID: 18292081
Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the...
3.
Ma Q, Harris-White M, Ubeda O, Simmons M, Beech W, Lim G, et al.
J Neurochem
. 2007 Sep;
103(4):1594-607.
PMID: 17760871
Extracellular-signal regulated kinase (ERK) signaling is critical for memory and tightly regulated by acute environmental stimuli. In Alzheimer disease transgenic models, active ERK is shown to first be increased, then...
4.
Zhao L, Ma Q, Calon F, Harris-White M, Yang F, Lim G, et al.
Nat Neurosci
. 2006 Jan;
9(2):234-42.
PMID: 16415866
Defects in dendritic spines are common to several forms of cognitive deficits, including mental retardation and Alzheimer disease. Because mutation of p21-activated kinase (PAK) can lead to mental retardation and...
5.
Ma Q, Lim G, Harris-White M, Yang F, Ambegaokar S, Ubeda O, et al.
J Neurosci Res
. 2005 Dec;
83(3):374-84.
PMID: 16385556
Although active and passive immunization against the beta-amyloid peptide (Abeta) of amyloid plaque-bearing transgenic mice markedly reduces amyloid plaque deposition and improves cognition, the mechanisms of neuroprotection and impact on...
6.
Cole G, Lim G, Yang F, Teter B, Begum A, Ma Q, et al.
Neurobiol Aging
. 2005 Nov;
26 Suppl 1:133-6.
PMID: 16266772
Alzheimer's disease (AD) and cardiovascular disease (CVD) are syndromes of aging that share analogous lesions and risk factors, involving lipoproteins, oxidative damage and inflammation. Unlike in CVD, in AD, sensitive...
7.
Calon F, Lim G, Morihara T, Yang F, Ubeda O, Salem Jr N, et al.
Eur J Neurosci
. 2005 Aug;
22(3):617-26.
PMID: 16101743
Epidemiological data indicate that low n-3 polyunsaturated fatty acids (PFA) intake is a readily manipulated dietary risk factor for Alzheimer's disease (AD). Studies in animals confirm the deleterious effect of...
8.
Lim G, Calon F, Morihara T, Yang F, Teter B, Ubeda O, et al.
J Neurosci
. 2005 Mar;
25(12):3032-40.
PMID: 15788759
Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD). DHA levels are lower...
9.
Morihara T, Teter B, Yang F, Lim G, Boudinot S, Boudinot F, et al.
Neuropsychopharmacology
. 2005 Feb;
30(6):1111-20.
PMID: 15688088
Epidemiological and basic research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) should protect against the most common forms of Alzheimer's disease (AD). Ibuprofen reduces amyloid (Abeta) pathology in some transgenic models,...
10.
Cole G, Morihara T, Lim G, Yang F, Begum A, Frautschy S
Ann N Y Acad Sci
. 2005 Feb;
1035:68-84.
PMID: 15681801
Both oxidative damage and inflammation are elevated in brains of Alzheimer's disease (AD) patients, but their pathogenic significance remains unclear. The reduced AD risk associated with high intake of both...