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Gisela Keller

Explore the profile of Gisela Keller including associated specialties, affiliations and a list of published articles. Areas
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Articles 78
Citations 1618
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Recent Articles
1.
Plum P, Monig S, Gockel I, Keller G, Ott K
Chirurgie (Heidelb) . 2024 Aug; 95(9):685-695. PMID: 39120691
Benign and malignant diseases of the upper gastrointestinal tract show gender-specific differences. The frequent gastroesophageal reflux disease is a prime example: men have an erosive reflux disease more often than...
2.
Grosser B, Heyer C, Austgen J, Sipos E, Reitsam N, Hauser A, et al.
Gastric Cancer . 2023 Oct; 27(1):72-85. PMID: 37874427
Background: Recently, we presented Stroma AReactive Invasion Front Areas (SARIFA) as a new histomorphologic negative prognostic biomarker in gastric cancer. It is defined as direct contact between tumor cells and...
3.
Kohlruss M, Chakraborty S, Hapfelmeier A, Jesinghaus M, Slotta-Huspenina J, Novotny A, et al.
J Cancer Res Clin Oncol . 2023 Oct; 149(20):17727-17737. PMID: 37819581
Purpose: We recently showed that low microsatellite instability (MSI-L) is associated with a good response to platinum/5-fluorouracil (5-FU) neoadjuvant chemotherapy (CTx) in gastric cancer. The purpose of this study was...
4.
Stogbauer F, Gess B, Brambs C, Lautizi M, Kacprowski T, Ourailidis I, et al.
Cancers (Basel) . 2023 Aug; 15(15). PMID: 37568650
The molecular characterization of endometrial endometrioid adenocarcinomas has provided major advances in its prognostic stratification. However, risk assessment of microsatellite instability (MSI) and copy-number (CN)-low cases remains a challenge. Thus,...
5.
Hess T, Maj C, Gehlen J, Borisov O, Haas S, Gockel I, et al.
EBioMedicine . 2023 Jul; 94:104709. PMID: 37480624
No abstract available.
6.
Griger J, Widholz S, Jesinghaus M, de Andrade Kratzig N, Lange S, Engleitner T, et al.
Cancer Cell . 2023 Jun; 41(7):1327-1344.e10. PMID: 37352862
Gastric neuroendocrine carcinomas (G-NEC) are aggressive malignancies with poorly understood biology and a lack of disease models. Here, we use genome sequencing to characterize the genomic landscapes of human G-NEC...
7.
Hess T, Maj C, Gehlen J, Borisov O, Haas S, Gockel I, et al.
EBioMedicine . 2023 May; 92:104616. PMID: 37209533
Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim...
8.
Hiltner T, Kohlruss M, Herz A, Lorenzen S, Novotny A, Hapfelmeier A, et al.
J Cancer Res Clin Oncol . 2023 Mar; 149(10):7651-7662. PMID: 37000259
Purpose: To investigate the prognostic role of microsatellite instability (MSI) in association with sex of patients treated with platinum/fluoropyrimidine neoadjuvant chemotherapy (CTx) with or without a taxane-containing compound. Methods: Of...
9.
Hiltner T, Szorenyi N, Kohlruss M, Hapfelmeier A, Herz A, Slotta-Huspenina J, et al.
Cancers (Basel) . 2023 Feb; 15(3). PMID: 36765729
We aimed to determine the clinical and prognostic relevance of allelic imbalance (AI) of the major histocompatibility complex (MHC) class I genes, encompassing the human leukocyte antigen (HLA) class I...
10.
Saldanha O, Muti H, Grabsch H, Langer R, Dislich B, Kohlruss M, et al.
Gastric Cancer . 2022 Oct; 26(2):264-274. PMID: 36264524
Background: Computational pathology uses deep learning (DL) to extract biomarkers from routine pathology slides. Large multicentric datasets improve performance, but such datasets are scarce for gastric cancer. This limitation could...