Gisela I Mazaira
Overview
Explore the profile of Gisela I Mazaira including associated specialties, affiliations and a list of published articles.
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18
Citations
168
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Recent Articles
1.
Galilea A, Santillan V, Acebedo S, Virginia Dansey M, Alvarez L, Mazaira G, et al.
Chembiochem
. 2024 Aug;
25(21):e202400018.
PMID: 39159394
Steroid hormones are essential for the biological processes of eukaryotic organisms. The steroid endocrine system of C. elegans, which includes dafachronic acids (DA) and the nuclear receptor ceDAF-12, provides a...
2.
Mazaira G, Erlejman A, Zgajnar N, Piwien-Pilipuk G, Galigniana M
Mol Cell Endocrinol
. 2023 Aug;
577:112047.
PMID: 37604241
The classic model of action of the glucocorticoid receptor (GR) sustains that its associated heat-shock protein of 90-kDa (HSP90) favours the cytoplasmic retention of the unliganded GR, whereas the binding...
3.
Ciucci S, Mazaira G, Galigniana M
Curr Rev Clin Exp Pharmacol
. 2023 Mar;
18(3):242-254.
PMID: 36929713
Glucocorticoid steroids play cardinal roles during the life span of an individual, modulating almost all aspects of the physiology, including the metabolism of carbohydrates, lipids and amino acids, as well...
4.
Mazaira G, Piwien Pilipuk G, Galigniana M
Trends Endocrinol Metab
. 2021 Aug;
32(10):827-838.
PMID: 34420854
Steroid receptors form soluble heterocomplexes with the 90-kDa heat-shock protein (Hsp90) and other chaperones and co-chaperones. The assembly and composition of the oligomer is influenced by the presence and nature...
5.
Mazaira G, Echeverria P, Ciucci S, Monte M, Gallo L, Erlejman A, et al.
Biochim Biophys Acta Mol Cell Res
. 2021 Mar;
1868(6):119000.
PMID: 33675851
A dimer of the heat-shock protein of 90-kDa (Hsp90) represents the critical core of the chaperone complex associated to the glucocorticoid receptor (GR) oligomer. The C-terminal end of the Hsp90...
6.
Mazaira G, Echeverria P, Galigniana M
J Cell Sci
. 2020 May;
133(12).
PMID: 32467326
It has been demonstrated that tetratricopeptide-repeat (TPR) domain proteins regulate the subcellular localization of glucocorticoid receptor (GR). This study analyses the influence of the TPR domain of high molecular weight...
7.
Gupta S, Swapanthi P, Bhagya D, Federicci F, Mazaira G, Galigniana M, et al.
Anticancer Agents Med Chem
. 2019 Nov;
20(3):369-385.
PMID: 31713499
Background: Heat shock protein 90 (Hsp90) is an encouraging anticancer target for the development of clinically significant molecules. Schiff bases play a crucial role in anticancer research because of their...
8.
Mazaira G, Galigniana M
Methods Mol Biol
. 2019 May;
1966:125-135.
PMID: 31041743
Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription...
9.
Mazaira G, Zgajnar N, Lotufo C, Daneri-Becerra C, Sivils J, Soto O, et al.
Methods Mol Biol
. 2019 May;
1966:1-5.
PMID: 31041734
In this chapter, we summarize the birth of the field of nuclear receptors. These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal...
10.
Mazaira G, Zgajnar N, Lotufo C, Daneri-Becerra C, Sivils J, Soto O, et al.
Nucl Receptor Res
. 2018 Aug;
5.
PMID: 30148160
In this article we summarize the birth of the field of nuclear receptors, the discovery of untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of the three-domain structure of...