Girish C Melkani
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Explore the profile of Girish C Melkani including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity
Halder S, Melkani G
Curr Obes Rep
. 2025 Mar;
14(1):21.
PMID: 40024983
Purpose Of Review: This review explores the complex interplay between genetic predispositions to obesity, circadian rhythms, metabolic regulation, and sleep. It highlights how genetic factors underlying obesity exacerbate metabolic dysfunction...
2.
Watson J, Roth J, Melkani G
J Vis Exp
. 2025 Feb;
(216).
PMID: 39995173
Immunostaining Drosophila melanogaster brains is essential for exploring the mechanisms behind complex behaviors, neural circuits, and protein expression patterns. Traditional methods often involve challenges such as performing complex dissection, maintaining...
3.
Gill S, Mandigo T, Elmali A, Leger B, Yang B, Tran S, et al.
medRxiv
. 2024 Dec;
PMID: 39711723
Congenital disorders of glycosylation (CDG) comprise a class of inborn errors of metabolism resulting from pathogenic variants in genes coding for enzymes involved in the asparagine-linked glycosylation of proteins. Unexpectedly...
4.
C M Moraes R, Roth J, Mao H, Crawley S, Xu B, Watson J, et al.
Genes (Basel)
. 2024 Nov;
15(11).
PMID: 39596576
Apolipoprotein E (ApoE) is the leading genetic risk factor for late-onset Alzheimer's disease (AD), which is the leading cause of dementia worldwide. Most people have two ApoE-ε3 (ApoE3) alleles, while...
5.
Livelo C, Guo Y, Madhanagopal J, Morrow C, Melkani G
Aging Cell
. 2024 Oct;
24(2):e14382.
PMID: 39446089
Recent research has highlighted the essential role of the microbiome in maintaining skeletal muscle physiology. The microbiota influences muscle health by regulating lipid metabolism, protein synthesis, and insulin sensitivity. However,...
6.
Bhide S, Chandran S, Rajasekaran N, Melkani G
Genes (Basel)
. 2024 Aug;
15(8).
PMID: 39202453
Nuclear lamins, a type V intermediate filament, are crucial components of the nuclear envelope's inner layer, maintaining nuclear integrity and mediating interactions between the nucleus and cytoplasm. Research on human...
7.
Melkani Y, Pant A, Guo Y, Melkani G
Commun Biol
. 2024 Jun;
7(1):702.
PMID: 38849449
The Drosophila model is pivotal in deciphering the pathophysiological underpinnings of various human ailments, notably aging and cardiovascular diseases. Cutting-edge imaging techniques and physiology yield vast high-resolution videos, demanding advanced...
8.
Guo Y, Abou Daya F, Le H, Panda S, Melkani G
Aging Cell
. 2024 Apr;
23(7):e14169.
PMID: 38616316
Circadian disruption is associated with an increased risk of cardiometabolic disorders and cardiac diseases. Time-restricted feeding/eating (TRF/TRE), restricting food intake within a consistent window of the day, has shown improvements...
9.
Guo Y, Livelo C, Melkani G
Bioessays
. 2023 Oct;
45(12):e2300157.
PMID: 37850554
Dysregulation of lipid metabolism is a commonly observed feature associated with metabolic syndrome and leads to the development of negative health outcomes such as obesity, diabetes mellitus, non-alcoholic fatty liver...
10.
Roth J, de Moraes R, Xu B, Crawley S, Khan M, Melkani G
Front Aging Neurosci
. 2023 Oct;
15:1223911.
PMID: 37823007
Huntington's disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the gene that leads to a...