Giovanni Bottegoni
Overview
Explore the profile of Giovanni Bottegoni including associated specialties, affiliations and a list of published articles.
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58
Citations
1276
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Recent Articles
1.
Varone E, Retini M, Cherubini A, Chernorudskiy A, Marrazza A, Guidarelli A, et al.
Cell Death Dis
. 2025 Feb;
16(1):105.
PMID: 39962052
Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide...
2.
Peter S, Siragusa L, Thomas M, Palomba T, Cross S, OBoyle N, et al.
J Chem Inf Model
. 2024 Oct;
64(21):8176-8192.
PMID: 39441864
The steadily growing number of experimental G-protein-coupled receptor (GPCR) structures has revealed diverse locations of allosteric modulation, and yet few drugs target them. This gap highlights the need for a...
3.
Zia S, Coricello A, Bottegoni G
Curr Opin Struct Biol
. 2024 Jun;
87:102871.
PMID: 38924980
By incorporating full flexibility and enabling the quantification of crucial parameters such as binding free energies and residence times, methods for investigating protein-ligand binding and unbinding via molecular dynamics provide...
4.
Lembo V, Bottegoni G
J Med Chem
. 2024 Jun;
67(12):10374-10385.
PMID: 38843874
Multitarget-directed ligands (MTDLs) are compounds rationally designed to affect multiple targets, aiming for a better therapeutic profile. For over 20 years, MTDLs have garnered increasing attention, the idea being that...
5.
Basagni F, Ortega J, Bertozzi S, Armirotti A, Summa M, Bertorelli R, et al.
Eur J Med Chem
. 2023 Sep;
261:115803.
PMID: 37734258
Neurodegenerative processes characterizing Alzheimer's disease (AD) are strictly related to the impairment of cholinergic and glutamatergic neurotransmitter systems which provoke synaptic loss. These experimental evidences still represent the foundation of...
6.
Buigues P, Gehrke S, Badaoui M, Dudas B, Mandana G, Qi T, et al.
J Chem Theory Comput
. 2023 Jul;
19(15):5260-5272.
PMID: 37458730
Patient symptom relief is often heavily influenced by the residence time of the inhibitor-target complex. For the human muscarinic receptor 3 (hMR3), tiotropium is a long-acting bronchodilator used in conditions...
7.
Lunerti V, Li H, Benvenuti F, Shen Q, Domi A, Soverchia L, et al.
Eur J Pharmacol
. 2022 Jun;
928:175088.
PMID: 35690082
Tobacco use disorder is a worldwide health problem for which available medications show limited efficacy. Nicotine is the psychoactive component of tobacco responsible for its addictive liability. Similar to other...
8.
Di Martino R, Cavalli A, Bottegoni G
Expert Opin Ther Pat
. 2022 Mar;
32(6):605-627.
PMID: 35235753
Introduction: Compelling evidence identified D3 dopamine receptor (D3R) as a suitable target for therapeutic intervention on CNS-associated disorders, cancer, and other conditions. Several efforts have been made toward developing potent...
9.
Inflammation causes remodeling of mitochondrial cytochrome oxidase mediated by the bifunctional gene
Clayton S, Daley K, MacDonald L, Fernandez-Vizarra E, Bottegoni G, ONeil J, et al.
Sci Adv
. 2021 Dec;
7(50):eabl5182.
PMID: 34878835
Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory diseases. Cytochrome oxidase (CO), which mediates the rate-limiting step in mitochondrial respiration, is remodeled during development and in response to changes...
10.
Di Fruscia P, Carbone A, Bottegoni G, Berti F, Giacomina F, Ponzano S, et al.
J Med Chem
. 2021 Sep;
64(18):13327-13355.
PMID: 34469137
Inhibition of intracellular -acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA) from degradation,...