Giorgia Giordano
Overview
Explore the profile of Giorgia Giordano including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
58
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Recent Articles
1.
Schiavon A, Saba L, Evaristo C, Petiti J, Pignochino Y, Ferrero G, et al.
Biomed Pharmacother
. 2025 Feb;
184:117917.
PMID: 39965324
Adrenocortical Carcinoma is a rare and aggressive endocrine malignancy, that arises from cells of one of the three cortical layers of the adrenal gland. Radical surgery is the only curative...
2.
Giordano G, Tucciarello C, Merlini A, Cutrupi S, Pignochino Y
Cell Commun Signal
. 2024 Sep;
22(1):433.
PMID: 39252029
Bone sarcomas are malignant tumors of mesenchymal origin. Complete surgical resection is the cornerstone of multidisciplinary treatment. However, advanced, unresectable forms remain incurable. A crucial step towards addressing this challenge...
3.
Racca L, Liuzzi E, Comparato S, Giordano G, Pignochino Y
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201617
Anticancer therapy urgently needs the development of novel strategies. An innovative molecular target is represented by circular RNAs (circRNAs), single-strand RNA molecules with the 5' and 3' ends joined, characterized...
4.
Pippione A, Vigato C, Tucciarello C, Hussain S, Salladini E, Truong H, et al.
ACS Med Chem Lett
. 2024 Aug;
15(8):1269-1278.
PMID: 39140045
AKR1C3 is an upregulated enzyme in prostate and other cancers; in addition to regulating hormone synthesis, this enzyme is thought to play a role in the aggressiveness of tumors and...
5.
Petiti J, Pignochino Y, Schiavon A, Giugliano E, Berrino E, Giordano G, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612443
Acute myeloid leukemia (AML) is a complex hematologic malignancy with high morbidity and mortality. Nucleophosmin 1 (NPM1) mutations occur in approximately 30% of AML cases, and NPM1-mutated AML is classified...
6.
Dichiara M, Cosentino G, Giordano G, Pasquinucci L, Marrazzo A, Costanzo G, et al.
Expert Opin Drug Discov
. 2023 Dec;
19(3):317-329.
PMID: 38145409
Introduction: With the increasing incidence and prevalence of neurological disorders globally, there is a paramount need for new pharmacotherapies. BBB effectively protects the brain but raises a profound challenge to...
7.
Saygin C, Giordano G, Shimamoto K, Eisfelder B, Thomas-Toth A, Venkataraman G, et al.
Clin Cancer Res
. 2023 Jun;
29(16):3151-3161.
PMID: 37363966
Purpose: Relapsed T-acute lymphoblastic leukemia (T-ALL) has limited treatment options. We investigated mechanisms of resistance to BH3 mimetics in T-ALL to develop rational combination strategies. We also looked at the...
8.
Mancarella C, Giusti V, Caldoni G, Laginestra M, Parra A, Toracchio L, et al.
Cancer Gene Ther
. 2023 Jun;
30(9):1285-1295.
PMID: 37353558
Ewing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with a poor prognosis and an elevated...
9.
Merlini A, Centomo M, Ferrero G, Chiabotto G, Miglio U, Berrino E, et al.
Front Oncol
. 2022 Sep;
12:844250.
PMID: 36110934
Background: Advanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet medical need. We demonstrated that the alkylating agent trabectedin and the PARP1-inhibitor olaparib display antitumor activity...
10.
Pignochino Y, Crisafulli G, Giordano G, Merlini A, Berrino E, Centomo M, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34944915
Drug-induced tumor mutational burden (TMB) may contribute to unleashing the immune response in relatively "immune-cold" tumors, such as sarcomas. We previously showed that PARP1 inhibition perpetuates the DNA damage induced...