Gillian M Arscott
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Explore the profile of Gillian M Arscott including associated specialties, affiliations and a list of published articles.
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9
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4242
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Recent Articles
1.
Marriott R, Murray K, Budgeon C, Codd V, Hui J, Arscott G, et al.
Eur J Endocrinol
. 2023 Feb;
188(2).
PMID: 36751991
Objective: Older men on an average have lower testosterone concentrations, compared with younger men, and more age-related comorbidities. Whether lower testosterone concentrations contribute to biological ageing remains unclear. Shorter telomeres...
2.
Yeap B, Hui J, Knuiman M, Flicker L, Divitini M, Arscott G, et al.
J Gerontol A Biol Sci Med Sci
. 2020 Aug;
76(1):164-171.
PMID: 32761187
Background: Telomeres are essential DNA-protein complexes whose attrition results in cellular dysfunction and senescence. Leukocyte telomere length (LTL) correlates with tissue telomere length, representing a biomarker for biological age. However,...
3.
Yeap B, Hui J, Knuiman M, S A Paul C, Ken K Y H, Flicker L, et al.
Eur J Endocrinol
. 2019 Oct;
182(1):23-33.
PMID: 31658437
Objective: Effects of insulin-like growth factor 1 (IGF1) and its binding proteins (IGFBPs) on ageing, and their interaction with sex hormones, remain uncertain. We examined associations of plasma IGF1, IGFBP1,...
4.
Yeap B, Hui J, Knuiman M, Handelsman D, Flicker L, Divitini M, et al.
Clin Endocrinol (Oxf)
. 2018 Dec;
90(4):562-569.
PMID: 30561819
Context: Telomeres protect chromosomes from damage, and shorter leucocyte telomere length (LTL) is a marker of advancing biological age. The association between testosterone (T) and its bioactive metabolites, dihydrotestosterone (DHT)...
5.
Yeap B, Knuiman M, Handelsman D, Ho K, Hui J, Divitini M, et al.
Clin Endocrinol (Oxf)
. 2018 Oct;
90(2):301-311.
PMID: 30353958
Context: Pituitary luteinizing hormone (LH) stimulates testicular production of testosterone (T) which is metabolized to dihydrotestosterone (DHT) by 5α-reductase and to oestradiol (E2) by aromatase. How the activity of population...
6.
Yeap B, Knuiman M, Divitini M, Hui J, Arscott G, Handelsman D, et al.
J Clin Endocrinol Metab
. 2016 Jan;
101(3):1299-306.
PMID: 26789780
Context: Advancing age is accompanied by an accumulation of ill health and shortening of chromosomal telomeres signifying biological aging. T is metabolized to DHT by 5α-reductase (SRD5A2) and to estradiol...
7.
Locke A, Kahali B, Berndt S, Justice A, Pers T, Day F, et al.
Nature
. 2015 Feb;
518(7538):197-206.
PMID: 25673413
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index...
8.
Shungin D, Winkler T, Croteau-Chonka D, Ferreira T, Locke A, Magi R, et al.
Nature
. 2015 Feb;
518(7538):187-196.
PMID: 25673412
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat...
9.
Wood A, Esko T, Yang J, Vedantam S, Pers T, Gustafsson S, et al.
Nat Genet
. 2014 Oct;
46(11):1173-86.
PMID: 25282103
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in...